{"doi":"10.3390/ijms262211014","title":"Hematological Biomarkers for Early Detection of Lung Cancer: Evaluating the Diagnostic Potential of Circulating Interleukin Levels","abstract":"Early detection of lung cancer remains a major unmet clinical need, as most patients are diagnosed at advanced stages when curative treatment options are limited. Circulating cytokines and interleukins represent promising molecular biomarkers for the non-invasive diagnosis and monitoring of tumor development. In this study, we investigated the diagnostic potential of plasma interleukins in distinguishing early-stage non-small cell lung cancer (NSCLC) from healthy individuals and patients with chronic obstructive pulmonary disease (COPD). Quantitative analyses demonstrated significantly elevated plasma levels of IL-1RA, IL-6, IL-8, IL-10, and IL-17A in NSCLC patients compared with healthy controls. Among these, a composite biomarker panel comprising IL-6, IL-10, IL-8, and IL-1RA exhibited the highest diagnostic performance, outperforming individual cytokines and other combinations. This interleukin-based signature also differentiated NSCLC from COPD with strong specificity, underscoring its potential clinical applicability. These findings highlight the molecular and translational relevance of plasma interleukin profiling as a non-invasive diagnostic approach for early lung cancer detection, potentially enabling earlier intervention and improved patient outcomes.","journal":"International Journal of Molecular Sciences","year":2025,"id":527520,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9555,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1404272,"name":"Yiwei Yang","orcid":"0000-0001-9930-0561","position":1,"is_corresponding":false},{"id":1404273,"name":"Rachid Lahlil","orcid":"0000-0003-2966-6386","position":2,"is_corresponding":false},{"id":1404274,"name":"Lakhiari Hamid","orcid":"0000-0003-0360-0733","position":3,"is_corresponding":false},{"id":1404846,"name":"H. Alaoui","orcid":null,"position":4,"is_corresponding":false},{"id":1404271,"name":"Ouafaa Morjani","orcid":"0009-0006-1811-6062","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T02:50:39.280101Z","pmid":"41303495","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}