{"doi":"10.3390/ijms262110322","title":"CDK4/6 Inhibitors in Breast Cancer—Who Should Receive Them?","abstract":"). Endocrine therapy that blocks estrogen signaling remains the cornerstone of treatment, yet relapses continue to affect many patients. Cyclin-dependent kinases 4 and 6 (CDK4/6) regulate the G1-S phase transition in the cell cycle, and pharmacological inhibition of this pathway has been successfully leveraged to reduce recurrence. CDK4/6 inhibitors combined with endocrine therapy are now the standard of care, although determining the optimal patient population for treatment remains a key challenge. A newly published study provides important insight, showing that loss of the NF1/neurofibromin tumor suppressor confers greater sensitivity to CDK4/6 inhibition, as these tumors rely heavily on CDK4/6 activity for survival under endocrine therapy.","journal":"International Journal of Molecular Sciences","year":2025,"id":547924,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9501,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":279916,"name":"Ze-Yi Zheng","orcid":null,"position":1,"is_corresponding":false},{"id":225687,"name":"Meenakshi Anurag","orcid":"0000-0003-4379-5192","position":2,"is_corresponding":false},{"id":1440687,"name":"Ahmed Elkhanany","orcid":"0000-0001-7681-6872","position":3,"is_corresponding":false},{"id":268044,"name":"Natalie Chen","orcid":"0000-0002-8961-6244","position":4,"is_corresponding":false},{"id":277761,"name":"Eric C. Chang","orcid":"0000-0002-1375-5088","position":5,"is_corresponding":false},{"id":1440686,"name":"Anran Chen","orcid":"0000-0002-6550-1370","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:53:53.962932Z","pmid":"41226361","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}