{"doi":"10.3390/ijms26157643","title":"Pro-Dermcidin as an Emerging Regulator of Innate Immunity in Sepsis","abstract":"Human dermcidin (DCD) is synthesized as a 110-amino acid precursor (pre-dermcidin, pre-DCD) containing a 19-residue leader signal sequence, which is removed to produce a leader-less pro-domain-containing peptide termed as pro-dermcidin, pro-DCD. Pro-DCD can be secreted by human eccrine sweat glands and then cleaved into antimicrobial peptides, such as dermcidin (DCD). Emerging evidence suggests that pro-DCD has broader physiological roles beyond antimicrobial defense, potentially serving as a therapeutic agent for inflammatory diseases like sepsis. In this review, we summarize recent evidence supporting pro-DCD as a regulator of innate immunity in sepsis.","journal":"International Journal of Molecular Sciences","year":2025,"id":542062,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1263791,"name":"Jianhua Li","orcid":"0000-0002-7750-1052","position":1,"is_corresponding":false},{"id":247451,"name":"Weiqiang Chen","orcid":"0000-0002-9469-8328","position":2,"is_corresponding":false},{"id":565053,"name":"Shu Zhu","orcid":"0000-0003-2211-9646","position":3,"is_corresponding":false},{"id":565052,"name":"Xiaoling Qiang","orcid":"0000-0001-9176-7407","position":4,"is_corresponding":false},{"id":109941,"name":"Haichao Wang","orcid":"0000-0002-0211-9000","position":5,"is_corresponding":false},{"id":1263525,"name":"Lou Li","orcid":null,"position":0,"is_corresponding":true}],"reference_count":52,"raw_metadata":null,"created_at":"2026-07-19T02:52:51.593043Z","pmid":"40806779","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}