{"doi":"10.3390/ijms26125597","title":"Effects of Elevated Glucose on Bacterial Respiratory Infections in Cystic Fibrosis and Chronic Airway Diseases","abstract":"People with diabetes are at increased risk of developing lung infections and have more severe complications. However, the link between these risks and outcomes is unknown. These trends are also seen in people with chronic lung diseases, including cystic fibrosis (CF); however, less is known about the underlying mechanism of disease in these cases. Traditional CF bacterial pathogens are often associated with worse disease outcomes in non-CF individuals with diabetes or hyperglycemia who have other acute or chronic airway disease, yet how diabetes and hyperglycemia further compound chronic CF infections is less clear. In this review, we focus on what has been observed clinically regarding bacterial respiratory infections and diabetes, and we discuss model systems used to study these relationships. We also review what is known about the role of diabetes in chronic CF lung disease and how information gleaned from the general population can inform future research directions in the new era of highly effective modulator therapies for CF.","journal":"International Journal of Molecular Sciences","year":2025,"id":539590,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9487,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":511587,"name":"Megan R. Kiedrowski","orcid":"0000-0003-4610-182X","position":1,"is_corresponding":false},{"id":1426633,"name":"Emily M. Hughes","orcid":"0000-0003-3085-902X","position":0,"is_corresponding":true}],"reference_count":112,"raw_metadata":null,"created_at":"2026-07-19T02:52:30.048313Z","pmid":"40565059","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}