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This review summarizes the essential functions and potential mechanisms of ADM in the occurrence and progression in cancer, and presents the associated therapeutic challenges.</jats:p>","journal":"International Journal of Molecular Sciences","year":2025,"id":645595,"datarank":0.3453877639491069,"base_score":2.302585092994046,"endowment":2.302585092994046,"self_citation_contribution":0.3453877639491069,"citation_network_contribution":0.0,"self_endowment_contribution":0.3453877639491069,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1681120,"name":"Weijia Yang","orcid":"0009-0005-6725-6208","position":1,"is_corresponding":false},{"id":1206990,"name":"Shiqi Wang","orcid":"0000-0002-0324-5420","position":2,"is_corresponding":false},{"id":1165926,"name":"Zhihe Zhao","orcid":"0009-0009-6866-8027","position":3,"is_corresponding":false},{"id":1681121,"name":"Wangyang Wang","orcid":"0009-0008-6930-9088","position":4,"is_corresponding":false},{"id":1681122,"name":"Mingxuan Shi","orcid":"0000-0001-9161-9906","position":5,"is_corresponding":false},{"id":109405,"name":"Yi Li","orcid":"0000-0002-6537-8800","position":6,"is_corresponding":false},{"id":1681119,"name":"Hanyi Li","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Adrenomedullin in Tumorigenesis and Cancer Progression","abstract":"<jats:p>The pathogenesis of cancer is intricately associated with a multitude of factors, and its precise mechanisms continue to be a central focus of rigorous scientific inquiry. Adrenomedullin (ADM), initially characterized as a potent vasodilator, has subsequently been recognized for its diverse biological functions, including roles in angiogenesis, osteogenesis, and immune modulation. Recent studies have shown that ADM, secreted by tumor cells, also plays an important role in regulating immune escape and angiogenesis in the tumor microenvironment, promoting tumor cell proliferation, resisting apoptosis, adapting to anoxic environments, and participating in the process of chemotherapy resistance. Consequently, ADM is implicated in the pathophysiology of various cancers. This review summarizes the essential functions and potential mechanisms of ADM in the occurrence and progression in cancer, and presents the associated therapeutic challenges.</jats:p>","is_dataset_classified":null,"base_score":1.791759469228055,"endowment":1.791759469228055,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40565016","pmcid":"PMC12193685","openalex_id":"https://openalex.org/W4411179278","authors":[],"funders":[{"funder_name":"Key Research and Development Program of Gansu Province (International Scientific and Technological Cooperation Category)","grant_id":"23YFWA0003","title":null},{"funder_name":"Key Research and Development Program of Gansu Province (International Scientific and Technological Cooperation Category)","grant_id":"24JRRA949","title":null},{"funder_name":"Key Research and Development Program of Gansu Province (International Scientific and Technological Cooperation Category)","grant_id":"2023-2-10","title":null},{"funder_name":"Key Research and Development Program of Gansu Province (International Scientific and Technological Cooperation Category)","grant_id":"2024-3-89","title":null},{"funder_name":"Key Research and Development Program of Gansu Province (International Scientific and Technological Cooperation Category)","grant_id":"20250168","title":null},{"funder_name":"the Key Research and Development Program of Gansu Province (International Scientific and Technological Cooperation Category)","grant_id":"No. 23YFWA0003","title":null},{"funder_name":"the Foundation of Hospital of Stomatology, Lanzhou University","grant_id":"No. 20250168","title":null},{"funder_name":"the Science&Technology Plan Project of Lanzhou","grant_id":"No. 2023-2-10","title":null}],"total_grants":8,"fwci":2.4655,"citation_percentile":0.89366806,"influential_citations":0,"citation_trend":[{"year":2025,"count":2},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/26/12/5552/pdf?version=1749561511","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/26/12/5552/pdf?version=1749561511","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/26/12/5552/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms26125552","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40565016","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12193685","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12193685","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12193685?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Neuropeptides and Animal Physiology","Cancer, Stress, Anesthesia, and Immune Response","Receptor Mechanisms and Signaling","Humans","Adrenomedullin","Neoplasms","Disease Progression","Animals","Tumor Microenvironment","Carcinogenesis","Neovascularization, Pathologic","Cell Proliferation"],"mesh_terms":["Animals","Humans","Neoplasms","Neovascularization, Pathologic","Disease Progression","Cell Proliferation","Adrenomedullin","Tumor Microenvironment","Carcinogenesis"],"keywords":["Adrenomedullin","Angiogenesis","Carcinogenesis","Cancer","Immune system","Tumor microenvironment","Cancer research","Tumor progression","Biology","Immunology","Medicine","Pathogenesis","Metastasis","Bioinformatics","Internal medicine","Receptor","Tumor","vasodilation","signaling pathways"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T09:27:20.797049Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}