{"doi":"10.3390/ijms26104662","title":"Emerging Roles of C-C Motif Ligand 11 (CCL11) in Cancers and Liver Diseases: Mechanisms and Therapeutic Implications","abstract":"<jats:p>C-C motif ligand 11 (CCL11) is a multifunctional chemokine that regulates immunity, angiogenesis, and tissue remodeling. In addition to its allergic inflammation role, CCL11 exhibits context-dependent dual functions in relation to cancer progression. In liver diseases, it mediates injury, fibrosis, and inflammation while serving as a disease biomarker. This review systematically examines CCL11–receptor interactions and their immunomodulatory mechanisms in cancers and hepatic pathologies. We highlight CCL11’s therapeutic potential as both a prognostic marker and immunotherapeutic target. By integrating molecular and clinical insights, this work advances the understanding of CCL11’s pathophysiological roles and facilitates targeted therapy development.</jats:p>","journal":"International Journal of Molecular Sciences","year":2025,"id":627008,"datarank":0.32958368660043297,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.0,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1468208,"name":"Kwan Man","orcid":"0000-0001-5663-6866","position":1,"is_corresponding":false},{"id":1060390,"name":"TP Ng","orcid":"0000-0001-9822-1335","position":2,"is_corresponding":false},{"id":139768,"name":"Jiaqi Wang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Emerging Roles of C-C Motif Ligand 11 (CCL11) in Cancers and Liver Diseases: Mechanisms and Therapeutic Implications","abstract":"<jats:p>C-C motif ligand 11 (CCL11) is a multifunctional chemokine that regulates immunity, angiogenesis, and tissue remodeling. In addition to its allergic inflammation role, CCL11 exhibits context-dependent dual functions in relation to cancer progression. In liver diseases, it mediates injury, fibrosis, and inflammation while serving as a disease biomarker. This review systematically examines CCL11–receptor interactions and their immunomodulatory mechanisms in cancers and hepatic pathologies. We highlight CCL11’s therapeutic potential as both a prognostic marker and immunotherapeutic target. By integrating molecular and clinical insights, this work advances the understanding of CCL11’s pathophysiological roles and facilitates targeted therapy development.</jats:p>","is_dataset_classified":null,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"40429807","pmcid":"PMC12111778","openalex_id":"https://openalex.org/W4410346432","authors":[],"funders":[{"funder_name":"Shenzhen Science and Technology Program","grant_id":"JCYJ20240813113042055","title":null},{"funder_name":"Shenzhen Science and Technology Program","grant_id":"T12-703/19R","title":null},{"funder_name":"Shenzhen Science and Technology Program","grant_id":"17109422","title":null},{"funder_name":"Shenzhen Science and Technology Program","grant_id":"17113924","title":null}],"total_grants":4,"fwci":4.0273,"citation_percentile":0.94772982,"influential_citations":0,"citation_trend":[{"year":2025,"count":2},{"year":2026,"count":6}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/26/10/4662/pdf?version=1747143567","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/26/10/4662/pdf?version=1747143567","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/26/10/4662/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms26104662","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/40429807","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/12111778","host_type":"repository"},{"url":"https://hub.hku.hk/handle/10722/356661","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC12111778","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC12111778?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Chemokine receptors and signaling","Cytokine Signaling Pathways and Interactions","Receptor Mechanisms and Signaling","Humans","Neoplasms","Liver Diseases","Animals","Chemokine CCL11"],"mesh_terms":["Animals","Humans","Liver Diseases","Neoplasms","Chemokine CCL11"],"keywords":["Cancer research","Computational biology","Motif (music)","Biology","Bioinformatics","Chemistry","Medicine","Cancer","Inflammation","therapeutic target","liver disease","Chemokine Ccl11"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T15:57:10.128859Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}