{"doi":"10.3390/ijms252413428","title":"Association of Computed Tomography Scan-Assessed Body Composition with Immune and PI3K/AKT Pathway Proteins in Distinct Breast Cancer Tumor Components","abstract":"This hypothesis-generating study aims to examine the extent to which computed tomography-assessed body composition phenotypes are associated with immune and phosphoinositide 3-kinase (PI3K)/protein kinase B (AKT) signaling pathways in breast tumors. A total of 52 patients with newly diagnosed breast cancer were classified into four body composition types: adequate (lowest two tertiles of total adipose tissue [TAT]) and highest two tertiles of total skeletal muscle [TSM] areas); high adiposity (highest tertile of TAT and highest two tertiles of TSM); low muscle (lowest tertile of TSM and lowest two tertiles of TAT); and high adiposity with low muscle (highest tertile of TAT and lowest tertile of TSM). Immune and PI3K/AKT pathway proteins were profiled in tumor epithelium and the leukocyte-enriched stromal microenvironment using GeoMx (NanoString). Linear mixed models were used to compare log2-transformed protein levels. Compared with the normal type, the low muscle type was associated with higher expression of INPP4B (log2-fold change = 1.14, p = 0.0003, false discovery rate = 0.028). Other significant associations included low muscle type with increased CTLA4 and decreased pan-AKT expression in tumor epithelium, and high adiposity with increased CD3, CD8, CD20, and CD45RO expression in stroma (p < 0.05; false discovery rate > 0.2). With confirmation, body composition can be associated with signaling pathways in distinct components of breast tumors, highlighting the potential utility of body composition in informing tumor biology and therapy efficacies.","journal":"International Journal of Molecular Sciences","year":2024,"id":507515,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9259,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1359371,"name":"Dongtao Ann Fu","orcid":null,"position":1,"is_corresponding":false},{"id":926570,"name":"Sara M. Falzarano","orcid":"0000-0003-1559-7754","position":2,"is_corresponding":false},{"id":588878,"name":"Runzhi Zhang","orcid":"0000-0002-0763-5928","position":3,"is_corresponding":false},{"id":328406,"name":"Susmita Datta","orcid":"0000-0002-7408-699X","position":4,"is_corresponding":false},{"id":273483,"name":"Weizhou Zhang","orcid":"0000-0002-8236-0346","position":5,"is_corresponding":false},{"id":504382,"name":"Angela R. Omilian","orcid":"0000-0001-6348-9411","position":6,"is_corresponding":false},{"id":926566,"name":"Livingstone Aduse‐Poku","orcid":"0000-0001-9787-1731","position":7,"is_corresponding":false},{"id":23318,"name":"Jiang Bian","orcid":"0000-0002-2238-5429","position":8,"is_corresponding":false},{"id":506157,"name":"Jerome Irianto","orcid":"0000-0002-4804-7225","position":9,"is_corresponding":false},{"id":1115616,"name":"Jaya Ruth Asirvatham","orcid":"0000-0002-2266-4014","position":10,"is_corresponding":false},{"id":251270,"name":"Martha Campbell‐Thompson","orcid":"0000-0001-6878-1235","position":11,"is_corresponding":false},{"id":420899,"name":"Ting‐Yuan David Cheng","orcid":"0000-0002-4105-828X","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T02:11:02.460057Z","pmid":"39769193","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}