{"doi":"10.3390/ijms251810009","title":"MIND Diet Impact on Multiple Sclerosis Patients: Biochemical Changes after Nutritional Intervention","abstract":"<jats:p>There is substantial evidence supporting the neuroprotective effects of the MIND diet in neurodegenerative diseases like Parkinson’s and Alzheimer’s. Our aim was to evaluate the impact of a nutritional intervention (NI) with this diet on multiple sclerosis (MS) patients. The study was conducted in two stages. In the first stage, two groups were included: MS patients before the NI (group A) and healthy control subjects (group B). In this stage, groups (A) and (B) were compared (case–control study). In the second stage, group (A) was assessed after the NI, with comparisons made between baseline and final measurements (before-and-after study). In the case–control stage (baseline evaluation), we found significant differences in fatigue scores (p &lt; 0.001), adherence to the MIND diet (p &lt; 0.001), the serum levels of brain-derived neurotrophic factor (BDNF) (p &lt; 0.001), and higher oxidative status in the MS group, with lower levels of reduced glutathione (p &lt; 0.001), reduced/oxidised glutathione ratio (p &lt; 0.001), and elevated levels of lipoperoxidation (p &lt; 0.002) and 8-hydroxy-2′-deoxyguanosine (p &lt; 0.025). The before-and-after intervention stage showed improvements in fatigue scores (p &lt; 0.001) and physical quality-of-life scores (MSQOL-54) (p &lt; 0.022), along with decreases in the serum levels of glial-derived neurotrophic factor (GDNF) (p &lt; 0.041), lipoperoxidation (p &lt; 0.046), and 8-hydroxy-2′-deoxyguanosine (p &lt; 0.05). Consumption of the MIND diet is linked to clinical and biochemical improvement in MS patients.</jats:p>","journal":"International Journal of Molecular Sciences","year":2024,"id":644247,"datarank":0.4461260886109083,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.05026748916861942,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.05026748916861942,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":11,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1676735,"name":"Sara Gómez-Melero","orcid":"0000-0003-1465-7110","position":1,"is_corresponding":false},{"id":1676736,"name":"Begoña Mª Escribano","orcid":"0000-0002-0966-0641","position":2,"is_corresponding":false},{"id":1676737,"name":"Alejandro Galvao-Carmona","orcid":"0000-0002-5126-1273","position":3,"is_corresponding":false},{"id":1150936,"name":"Cristina Conde","orcid":"0000-0003-3633-1146","position":4,"is_corresponding":false},{"id":1676738,"name":"Mª Ángeles Peña-Toledo","orcid":null,"position":5,"is_corresponding":false},{"id":1676739,"name":"Noelia Villarrubia","orcid":"0000-0002-2114-8632","position":6,"is_corresponding":false},{"id":927812,"name":"Luisa María Villar","orcid":"0000-0002-9067-3668","position":7,"is_corresponding":false},{"id":1676740,"name":"Isaac Túnez","orcid":null,"position":8,"is_corresponding":false},{"id":1676741,"name":"Eduardo Agüera-Morales","orcid":null,"position":9,"is_corresponding":false},{"id":1676742,"name":"Javier Caballero-Villarraso","orcid":"0000-0003-0571-5147","position":10,"is_corresponding":false},{"id":1676734,"name":"Ainoa Navarrete-Pérez","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"MIND Diet Impact on Multiple Sclerosis Patients: Biochemical Changes after Nutritional Intervention","abstract":"<jats:p>There is substantial evidence supporting the neuroprotective effects of the MIND diet in neurodegenerative diseases like Parkinson’s and Alzheimer’s. Our aim was to evaluate the impact of a nutritional intervention (NI) with this diet on multiple sclerosis (MS) patients. The study was conducted in two stages. In the first stage, two groups were included: MS patients before the NI (group A) and healthy control subjects (group B). In this stage, groups (A) and (B) were compared (case–control study). In the second stage, group (A) was assessed after the NI, with comparisons made between baseline and final measurements (before-and-after study). In the case–control stage (baseline evaluation), we found significant differences in fatigue scores (p &lt; 0.001), adherence to the MIND diet (p &lt; 0.001), the serum levels of brain-derived neurotrophic factor (BDNF) (p &lt; 0.001), and higher oxidative status in the MS group, with lower levels of reduced glutathione (p &lt; 0.001), reduced/oxidised glutathione ratio (p &lt; 0.001), and elevated levels of lipoperoxidation (p &lt; 0.002) and 8-hydroxy-2′-deoxyguanosine (p &lt; 0.025). The before-and-after intervention stage showed improvements in fatigue scores (p &lt; 0.001) and physical quality-of-life scores (MSQOL-54) (p &lt; 0.022), along with decreases in the serum levels of glial-derived neurotrophic factor (GDNF) (p &lt; 0.041), lipoperoxidation (p &lt; 0.046), and 8-hydroxy-2′-deoxyguanosine (p &lt; 0.05). Consumption of the MIND diet is linked to clinical and biochemical improvement in MS patients.</jats:p>","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"39337497","pmcid":"PMC11431943","openalex_id":"https://openalex.org/W4402616604","authors":[],"funders":[{"funder_name":"Grant for neurological research","grant_id":"SAN (Andalusian Society of Neurology)-2022","title":null},{"funder_name":"SAN (Andalusian Society of Neurology)","grant_id":"","title":null}],"total_grants":2,"fwci":4.9336,"citation_percentile":0.94664349,"influential_citations":0,"citation_trend":[{"year":2025,"count":9},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/25/18/10009/pdf?version=1726654472","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/25/18/10009/pdf?version=1726654472","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/25/18/10009/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms251810009","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/39337497","host_type":"repository"},{"url":"http://hdl.handle.net/10396/32460","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/11431943","host_type":"repository"},{"url":"http://helvia.uco.es/xmlui/bitstream/10396/32460/1/ijms-25-10009-v2.pdf","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC11431943/pdf/ijms-25-10009.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC11431943","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC11431943?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Sesame and Sesamin Research","Multiple Sclerosis Research Studies","Liver Disease Diagnosis and Treatment"],"mesh_terms":["Adult","Female","Glutathione","Humans","Male","Middle Aged","Multiple Sclerosis","Case-Control Studies","Oxidative Stress","Brain-Derived Neurotrophic Factor"],"keywords":["Multiple sclerosis","Intervention (counseling)","Medicine","Gerontology","Bioinformatics","Physiology","Psychology","Biology","Psychiatry","Oxidative stress","Neurotrophic factors","Quality of life","Fatigue","Serum Biomarkers","Lifestyles","Dietary Intervention","Neurofilaments","Mind Diet"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-09T00:43:18.274271Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}