{"doi":"10.3390/ijms25179649","title":"C-C Chemokine Receptor 7 Promotes T-Cell Acute Lymphoblastic Leukemia Invasion of the Central Nervous System via β2-Integrins","abstract":"C-C Chemokine Receptor 7 (CCR7) mediates T-cell acute lymphoblastic leukemia (T-ALL) invasion of the central nervous system (CNS) mediated by chemotactic migration to C-C chemokine ligand 19 (CCL19). To determine if a CCL19 antagonist, CCL198-83, could inhibit CCR7-induced chemotaxis and signaling via CCL19 but not CCL21, we used transwell migration and Ca2+ mobilization signaling assays. We found that in response to CCL19, human T-ALL cells employ β2 integrins to invade human brain microvascular endothelial cell monolayers. In vivo, using an inducible mouse model of T-ALL, we found that we were able to increase the survival of the mice treated with CCL198-83 when compared to non-treated controls. Overall, our results describe a targetable cell surface receptor, CCR7, which can be inhibited to prevent β2-integrin-mediated T-ALL invasion of the CNS and potentially provides a platform for the pharmacological inhibition of T-ALL cell entry into the CNS.","journal":"International Journal of Molecular Sciences","year":2024,"id":471830,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9634,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1306980,"name":"Alondra Rodriguez","orcid":null,"position":1,"is_corresponding":false},{"id":1306981,"name":"V. Torres","orcid":null,"position":2,"is_corresponding":false},{"id":1306982,"name":"Anahi Sanchez","orcid":null,"position":3,"is_corresponding":false},{"id":1306578,"name":"Ángel Freddy Rodríguez Torres","orcid":"0000-0001-5047-2629","position":4,"is_corresponding":false},{"id":1306983,"name":"Aaron E. Vazquez","orcid":null,"position":5,"is_corresponding":false},{"id":294739,"name":"Amy Wagler","orcid":"0000-0001-9799-6059","position":6,"is_corresponding":false},{"id":1306984,"name":"Michael Abraham Brissette","orcid":null,"position":7,"is_corresponding":false},{"id":773933,"name":"Colin A. Bill","orcid":"0000-0003-0645-0363","position":8,"is_corresponding":false},{"id":773934,"name":"Charlotte M. Vines","orcid":"0000-0002-7902-8713","position":9,"is_corresponding":false},{"id":1306577,"name":"Cesar I. Cardona","orcid":"0000-0002-0965-9763","position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:05:48.788780Z","pmid":"39273598","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}