{"doi":"10.3390/ijms25168994","title":"The Regulation of MicroRNA-21 by Interleukin-6 and Its Role in the Development of Fibrosis in Endometriotic Lesions","abstract":"Endometriosis is one of the most common causes of chronic pelvic pain and infertility that affects 10% of women of reproductive age. It is currently defined as the presence of endometrial epithelial and stromal cells at ectopic sites; however, advances in endometriosis research have some authors believing that endometriosis should be re-defined as “a fibrotic condition in which endometrial stroma and epithelium can be identified”. microRNAs (miRNAs) are regulatory molecules that potentially play a role in endometriotic lesion development. There is evidence that suggests that miRNAs, including microRNA-21 (miR-21), participate in fibrotic processes in different organs, including the heart, kidney, liver and lungs. The objective of this study was to understand the role of miR-21 and the mechanisms that can contribute to the development of fibrosis by determining how IL-6 regulates miR-21 expression and how this miRNA regulates the transforming growth factor beta (TGF-β) signaling pathway to promote fibrosis. We investigated the expression of miR-21 in the baboon and mouse model of endometriosis and its correlation with fibrosis. We demonstrated that inflammation and fibrosis are present at a very early stage of endometriosis and that the inflammatory environment in the peritoneal cavity, which includes interleukin 6 (IL-6), can regulate the expression of miR-21 in vitro and in vivo.","journal":"International Journal of Molecular Sciences","year":2024,"id":437138,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9597,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":457402,"name":"Yong Song","orcid":"0000-0001-5841-436X","position":1,"is_corresponding":false},{"id":457404,"name":"Niraj Joshi","orcid":"0000-0002-2334-6819","position":2,"is_corresponding":false},{"id":901842,"name":"Gregory W. Burns","orcid":"0000-0003-0021-4319","position":3,"is_corresponding":false},{"id":428045,"name":"Emmanuel N. Paul","orcid":"0000-0001-5714-4994","position":4,"is_corresponding":false},{"id":499720,"name":"Erin L. Vegter","orcid":"0009-0005-1405-4645","position":5,"is_corresponding":false},{"id":500356,"name":"Samantha Hrbek","orcid":null,"position":6,"is_corresponding":false},{"id":299642,"name":"Lorenzo F. Sempere","orcid":"0000-0002-2150-0122","position":7,"is_corresponding":false},{"id":238614,"name":"Asgerally T. Fazleabas","orcid":null,"position":8,"is_corresponding":false},{"id":235146,"name":"Maria Ariadna Ochoa-Bernal","orcid":"0000-0002-9070-7135","position":0,"is_corresponding":true}],"reference_count":73,"raw_metadata":null,"created_at":"2026-07-19T02:00:29.872940Z","pmid":"39201680","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}