{"doi":"10.3390/ijms25042351","title":"SARS-CoV-2 ORF7a Mutation Found in BF.5 and BF.7 Sublineages Impacts Its Functions","abstract":"A feature of the SARS-CoV-2 Omicron subvariants BF.5 and BF.7 that recently circulated mainly in China and Japan was the high prevalence of the ORF7a: H47Y mutation, in which the 47th residue of ORF7a has been mutated from a histidine (H) to a tyrosine (Y). Here, we evaluated the effect of this mutation on the three main functions ascribed to the SARS-CoV-2 ORF7a protein. Our findings show that H47Y mutation impairs the ability of SARS-CoV-2 ORF7a to antagonize the type I interferon (IFN-I) response and to downregulate major histocompatibility complex I (MHC-I) cell surface levels, but had no effect in its anti-SERINC5 function. Overall, our results suggest that the H47Y mutation of ORF7a affects important functions of this protein, resulting in changes in virus pathogenesis.","journal":"International Journal of Molecular Sciences","year":2024,"id":478422,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":572563,"name":"Emily B. Ivey","orcid":"0000-0003-4426-2099","position":1,"is_corresponding":false},{"id":1311689,"name":"Sean R. Duffy","orcid":null,"position":2,"is_corresponding":false},{"id":1177128,"name":"Arnon Plianchaisuk","orcid":"0009-0004-2416-0508","position":3,"is_corresponding":false},{"id":258983,"name":"Jumpei Ito","orcid":"0000-0003-0440-8321","position":4,"is_corresponding":false},{"id":37911,"name":"Kei Sato","orcid":"0000-0003-4431-1380","position":5,"is_corresponding":false},{"id":257757,"name":"Spyridon Stavrou","orcid":"0000-0002-3962-8917","position":6,"is_corresponding":false},{"id":572562,"name":"Uddhav Timilsina","orcid":"0000-0002-9587-7600","position":0,"is_corresponding":true}],"reference_count":72,"raw_metadata":null,"created_at":"2026-07-19T02:06:42.155024Z","pmid":"38397027","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}