{"doi":"10.3390/ijms242417307","title":"Exosomes from Von Hippel-Lindau-Null Cancer Cells Promote Metastasis in Renal Cell Carcinoma","abstract":"Exosomes are extracellular vesicles that modulate essential physiological and pathological signals. Communication between cancer cells that express the von Hippel-Lindau (VHL) tumor suppressor gene and those that do not is instrumental to distant metastasis in renal cell carcinoma (RCC). In a novel metastasis model, VHL(−) cancer cells are the metastatic driver, while VHL(+) cells receive metastatic signals from VHL(−) cells and undergo aggressive transformation. This study investigates whether exosomes could be mediating metastatic crosstalk. Exosomes isolated from paired VHL(+) and VHL(−) cancer cell lines were assessed for physical, biochemical, and biological characteristics. Compared to the VHL(+) cells, VHL(−) cells produce significantly more exosomes that augment epithelial-to-mesenchymal transition (EMT) and migration of VHL(+) cells. Using a Cre-loxP exosome reporter system, the fluorescent color conversion and migration were correlated with dose-dependent delivery of VHL(−) exosomes. VHL(−) exosomes even induced a complete cascade of distant metastasis when added to VHL(+) tumor xenografts in a duck chorioallantoic membrane (dCAM) model, while VHL(+) exosomes did not. Therefore, this study supports that exosomes from VHL(−) cells could mediate critical cell-to-cell crosstalk to promote metastasis in RCC.","journal":"International Journal of Molecular Sciences","year":2023,"id":345414,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.94,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":822203,"name":"Moe Ishihara","orcid":"0000-0003-3893-2666","position":1,"is_corresponding":false},{"id":732795,"name":"Zhicheng Zhang","orcid":"0000-0003-1630-0385","position":2,"is_corresponding":false},{"id":1085392,"name":"Elizabeth S. Bowen","orcid":null,"position":3,"is_corresponding":false},{"id":753099,"name":"Aimee Wu","orcid":null,"position":4,"is_corresponding":false},{"id":1085393,"name":"Tala Ayoub","orcid":null,"position":5,"is_corresponding":false},{"id":992250,"name":"Julian Huang","orcid":null,"position":6,"is_corresponding":false},{"id":1085394,"name":"Celine Cano-Ruiz","orcid":null,"position":7,"is_corresponding":false},{"id":1085395,"name":"Maia Jackson","orcid":null,"position":8,"is_corresponding":false},{"id":1085396,"name":"Kaveeya Reghu","orcid":null,"position":9,"is_corresponding":false},{"id":1085397,"name":"Yasmeen Ayoub","orcid":null,"position":10,"is_corresponding":false},{"id":241821,"name":"Yazhen Zhu","orcid":"0000-0002-2130-8085","position":11,"is_corresponding":false},{"id":241820,"name":"Hsian‐Rong Tseng","orcid":"0000-0003-0942-5905","position":12,"is_corresponding":false},{"id":266761,"name":"Z. Hong Zhou","orcid":"0000-0002-8373-4717","position":13,"is_corresponding":false},{"id":468193,"name":"Junhui Hu","orcid":"0000-0001-9260-2858","position":14,"is_corresponding":false},{"id":468198,"name":"Lily Wu","orcid":"0000-0002-7963-5580","position":15,"is_corresponding":false},{"id":1084899,"name":"Kailey Flora","orcid":"0000-0003-3576-8987","position":0,"is_corresponding":true}],"reference_count":55,"raw_metadata":null,"created_at":"2026-07-19T01:11:39.484741Z","pmid":"38139136","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}