{"doi":"10.3390/ijms242216286","title":"A Berberine-Loaded Bletilla striata Polysaccharide Hydrogel as a New Medical Dressing for Diabetic Wound Healing","abstract":"The healing process of a diabetic wound (DW) is often impeded by a series of interrelated factors, including severe infection, persistent inflammation, and excessive oxidative stress. Therefore, it is particularly crucial to develop a medical dressing that can address these issues simultaneously. To this end, different ratios of Bletilla striata polysaccharide (BSP) and berberine (BER) were physically blended with Carbomer 940 (CBM940) to develop a composite hydrogel as a medical dressing. The BSP/BER hydrogel was characterized using SEM, FTIR, rheological testing and other techniques. The anti-inflammatory, antioxidant, and antibacterial properties of the hydrogel were evaluated using cell and bacterial models in vitro. A DW model of ICR mice was established to evaluate the effect of the hydrogel on DW healing in vivo. The hydrogel exhibited excellent biocompatibility and remarkable antibacterial, anti-inflammatory, and antioxidant properties. In addition, animal experiments showed that the BSP/BER hydrogel significantly accelerated wound healing in DW mice. Among the different formulations, the LBSP/BER hydrogel (2% BSP, mBER:mBSP = 1:40) demonstrated the most remarkable efficacy. In conclusion, the BSP/BER hydrogel developed exhibited immense properties and great potential as a medical dressing for the repair of DW, addressing a crucial need in clinical practice.","journal":"International Journal of Molecular Sciences","year":2023,"id":322566,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":40,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9526,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1036291,"name":"Kai Zhao","orcid":"0000-0002-4456-8461","position":1,"is_corresponding":false},{"id":1036710,"name":"Xingcan Chen","orcid":null,"position":2,"is_corresponding":false},{"id":666654,"name":"Mingyuan Zhou","orcid":"0000-0002-4253-2780","position":3,"is_corresponding":false},{"id":473256,"name":"Yu‐Chi Chen","orcid":"0000-0003-0010-9308","position":4,"is_corresponding":false},{"id":1036292,"name":"Xiaoqing Ye","orcid":"0000-0002-5912-3895","position":5,"is_corresponding":false},{"id":1036293,"name":"Fangmei Zhou","orcid":"0000-0002-2596-7029","position":6,"is_corresponding":false},{"id":1036294,"name":"Zhishan Ding","orcid":"0000-0001-5740-1479","position":7,"is_corresponding":false},{"id":1036295,"name":"Bingqi Zhu","orcid":"0009-0006-9127-2029","position":8,"is_corresponding":false},{"id":909951,"name":"Zhengbo Hu","orcid":null,"position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T01:07:42.497873Z","pmid":"38003478","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}