{"doi":"10.3390/ijms24076757","title":"Extracellular Vesicles as Potential Bladder Cancer Biomarkers: Take It or Leave It?","abstract":"<jats:p>Bladder cancer (BC) is the 10th most frequently diagnosed cancer worldwide. Although urine cytology and cystoscopy are current standards for BC diagnosis, both have limited sensitivity to detect low-grade and small tumors. Moreover, effective prognostic biomarkers are lacking. Extracellular vesicles (EVs) are lipidic particles that contain nucleic acids, proteins, and metabolites, which are released by cells into the extracellular space, being crucial effectors in intercellular communication. These particles have emerged as potential tools carrying biomarkers for either diagnosis or prognosis in liquid biopsies namely urine, plasma, and serum. Herein, we review the potential of liquid biopsies EVs’ cargo as BC diagnosis and prognosis biomarkers. Additionally, we address the emerging advantages and downsides of using EVs within this framework.</jats:p>","journal":"International Journal of Molecular Sciences","year":2023,"id":45782,"datarank":0.5366683536353999,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.12078004529943266,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.12078004529943266,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":15,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":213314,"name":"Catarina Lourenço","orcid":"0000-0003-0644-0202","position":1,"is_corresponding":false},{"id":213315,"name":"Miguel Carlos Oliveira","orcid":"0000-0001-5343-9680","position":2,"is_corresponding":false},{"id":213316,"name":"Rui Henrique","orcid":"0000-0003-3171-4666","position":3,"is_corresponding":false},{"id":87369,"name":"Carmen Jeronimo","orcid":"0000-0003-4186-5345","position":4,"is_corresponding":false},{"id":213313,"name":"Ana Teixeira-Marques","orcid":"0000-0003-1396-3466","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"37047731","pmcid":"PMC10094914","openalex_id":"https://openalex.org/W4362620587","authors":[],"funders":[{"funder_name":"Research Center of the Portuguese Oncology Institute of Porto","grant_id":"PI 27-CI- IPOP-27-2016","title":null},{"funder_name":"Research Center of the Portuguese Oncology Institute of Porto","grant_id":"PI 160-CI-IPOP-153-2021","title":null},{"funder_name":"Research Center of the Portuguese Oncology Institute of Porto","grant_id":"NORTE-01-0145-FEDER-072678","title":null},{"funder_name":"Research Center of the Portuguese Oncology Institute of Porto","grant_id":"PTDC/MEC-ONC/0491/2021","title":"GLYCOTARGET. A NEW FRONTIER IN EXTRACELLULAR VESICLE-MEDIATED CANCER IMMUNOMODULATION"},{"funder_name":"Research Center of the Portuguese Oncology Institute of Porto","grant_id":"2021.06731.BD","title":"EMBRACIVE – A microfluidic assisted technology for non-invasive identification and characterization of plasma extracellular vesicles in bladder cancer patients"}],"total_grants":5,"fwci":2.1139,"citation_percentile":0.87058358,"influential_citations":0,"citation_trend":[{"year":2023,"count":3},{"year":2024,"count":2},{"year":2025,"count":7},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/24/7/6757/pdf?version=1680621855","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/24/7/6757/pdf?version=1680621855","host_type":"GOLD"},{"url":"https://www.mdpi.com/1422-0067/24/7/6757/pdf?version=1680621855","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/24/7/6757/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms24076757","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/37047731","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/10094914","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/ijms24076757","host_type":"repository"},{"url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC10094914/pdf/ijms-24-06757.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC10094914","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC10094914?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3390/ijms24076757","host_type":""}],"fields_of_study":["Extracellular vesicles in disease","Bladder and Urothelial Cancer Treatments","Ferroptosis and cancer prognosis","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences","Humans","Biomarkers, Tumor","Urinary Bladder","Urinary Bladder Neoplasms","Biomarkers","Liquid Biopsy","Extracellular Vesicles"],"mesh_terms":["Extracellular Vesicles","Liquid Biopsy","Urinary Bladder","Urinary Bladder Neoplasms","Humans","Biomarkers, Tumor","Biomarkers"],"keywords":["Extracellular vesicles","Bladder cancer","Cystoscopy","Liquid biopsy","Extracellular vesicle","Microvesicles","Extracellular","Urine cytology","Diagnostic biomarker","Cancer biomarkers","Urine","Cancer","Biomarker","Medicine","Pathology","Cancer research","Biology","Internal medicine","microRNA","Cell biology","Urinary system","Biochemistry","Protein","miRNA","Biomarkers","Lncrna","Liquid Biopsies","Urinary Bladder Neoplasms","Urinary Bladder","Biomarkers, Tumor","Humans","Review"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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