{"doi":"10.3390/ijms24076407","title":"Short, Lipidated Dendrimeric γ-AApeptides as New Antimicrobial Peptidomimetics","abstract":"Antibiotic resistance is one of the most significant issues encountered in global health. There is an urgent demand for the development of a new generation of antibiotic agents combating the emergence of drug resistance. In this article, we reported the design of lipidated dendrimeric γ-AApeptides as a new class of antimicrobial agents. These AApeptides showed excellent potency and broad-spectrum activity against both Gram-positive bacteria and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). The mechanistic studies revealed that the dendrimeric AApeptides could kill bacteria rapidly through the permeabilization of bacterial membranes, analogous to host-defense peptides (HDPs). These dendrimers also did not induce antibiotic resistance readily. The easy access to the synthesis, together with their potent and broad-spectrum activity, make these lipidated dendrimeric γ-AApeptides a new generation of antibacterial agents.","journal":"International Journal of Molecular Sciences","year":2023,"id":365369,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.95,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":951454,"name":"Menglin Xue","orcid":null,"position":1,"is_corresponding":false},{"id":261770,"name":"Ruixuan Gao","orcid":"0000-0001-7137-2512","position":2,"is_corresponding":false},{"id":1115237,"name":"Soumyadeep Chakraborty","orcid":"0000-0002-3882-7172","position":3,"is_corresponding":false},{"id":1120881,"name":"Shaohui Wang","orcid":"0000-0003-0170-3309","position":4,"is_corresponding":false},{"id":306006,"name":"Xue Zhao","orcid":"0000-0001-9453-5548","position":5,"is_corresponding":false},{"id":422935,"name":"Meng Gu","orcid":null,"position":6,"is_corresponding":false},{"id":436096,"name":"Chuanhai Cao","orcid":"0000-0002-5765-6401","position":7,"is_corresponding":false},{"id":653526,"name":"Xingmin Sun","orcid":"0000-0002-8900-9161","position":8,"is_corresponding":false},{"id":300813,"name":"Jianfeng Cai","orcid":"0000-0003-3106-3306","position":9,"is_corresponding":false},{"id":771888,"name":"Yafeng Wang","orcid":"0000-0001-9301-9736","position":0,"is_corresponding":true}],"reference_count":14,"raw_metadata":null,"created_at":"2026-07-19T01:14:46.760245Z","pmid":"37047380","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}