{"doi":"10.3390/ijms24076159","title":"Mn(III) Porphyrin, MnTnBuOE-2-PyP5+, Commonly Known as a Mimic of Superoxide Dismutase Enzyme, Protects Cardiomyocytes from Hypoxia/Reoxygenation Induced Injury via Reducing Oxidative Stress","abstract":"Myocardial ischemia-reperfusion injury (I/R) causes damage to cardiomyocytes through oxidative stress and apoptosis. We investigated the cardioprotective effects of MnTnBuOE-2-PyP5+ (BMX-001), a superoxide dismutase mimic, in an in vitro model of I/R injury in H9c2 cardiomyocytes. We found that BMX-001 protected against hypoxia/reoxygenation (H/R)-induced oxidative stress, as evident by a significant reduction in intracellular and mitochondrial superoxide levels. BMX-001 pre-treatment also reduced H/R-induced cardiomyocyte apoptosis, as marked by a reduction in TUNEL-positive cells. We further demonstrated that BMX-001 pre-treatment significantly improved mitochondrial function, particularly O2 consumption, in mouse adult cardiomyocytes subjected to H/R. BMX-001 treatment also attenuated cardiolipin peroxidation, 4-hydroxynonenal (4-HNE) level, and 4-HNE adducted proteins following H/R injury. Finally, the pre-treatment with BMX-001 improved cell viability and lactate dehydrogenase (LDH) activity in H9c2 cells following H/R injury. Our findings suggest that BMX-001 has therapeutic potential as a cardioprotective agent against oxidative stress-induced H/R damage in H9c2 cardiomyocytes.","journal":"International Journal of Molecular Sciences","year":2023,"id":380301,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9524,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":861843,"name":"Papori Sharma","orcid":"0000-0002-8934-2001","position":1,"is_corresponding":false},{"id":827651,"name":"Utsab Subedi","orcid":"0000-0002-3223-9716","position":2,"is_corresponding":false},{"id":291376,"name":"Susmita Bhattarai","orcid":"0000-0002-5667-3218","position":3,"is_corresponding":false},{"id":862507,"name":"Chloe Miller","orcid":null,"position":4,"is_corresponding":false},{"id":925181,"name":"Shrivats Manikandan","orcid":null,"position":5,"is_corresponding":false},{"id":380443,"name":"Ines Batinic̈‐Haberle","orcid":"0000-0001-8037-1861","position":6,"is_corresponding":false},{"id":323968,"name":"Ivan Spasojević","orcid":"0000-0001-9890-6246","position":7,"is_corresponding":false},{"id":753437,"name":"Hong Sun","orcid":"0000-0001-9015-0480","position":8,"is_corresponding":false},{"id":291383,"name":"Manikandan Panchatcharam","orcid":"0000-0002-7691-8948","position":9,"is_corresponding":false},{"id":291384,"name":"Sumitra Miriyala","orcid":"0000-0001-7158-9295","position":10,"is_corresponding":false},{"id":826993,"name":"Sudha Sharma","orcid":"0000-0002-3359-9545","position":0,"is_corresponding":true}],"reference_count":60,"raw_metadata":null,"created_at":"2026-07-19T01:17:00.789848Z","pmid":"37047131","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}