{"doi":"10.3390/ijms232416005","title":"Novel Virulence Factors Deciphering Klebsiella pneumoniae KpC4 Infect Maize as a Crossing-Kingdom Pathogen: An Emerging Environmental Threat","abstract":"<jats:p>Klebsiella pneumoniae is not only a human and animal opportunistic pathogen, but a food-borne pathogen. Cross-kingdom infection has been focused on since K. pneumoniae was identified as the pathogen of maize, banana, and pomegranate. Although the pathogenicity of K. pneumoniae strains (from ditch water, maize, and human) on plant and mice has been confirmed, there are no reports to explain the molecular mechanisms of the pathogen. This study uncovered the K. pneumoniae KpC4 isolated from maize top rot for the determination of various virulence genes and resistance genes. At least thirteen plant disease-causing genes are found to be involved in the disruption of plant defense. Among them, rcsB is responsible for causing disease in both plants and animals. The novel sequence types provide solid evidence that the pathogen invades plant and has robust ecological adaptability. It is imperative to perform further studies on the verification of these KpC4 genes’ functions to understand the molecular mechanisms involved in plant–pathogen interactions.</jats:p>","journal":"International Journal of Molecular Sciences","year":2022,"id":16843,"datarank":0.37218692208033477,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.06027069082835936,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.06027069082835936,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":6,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":122724,"name":"Pengfei He","orcid":null,"position":1,"is_corresponding":false},{"id":122725,"name":"Pengbo He","orcid":null,"position":2,"is_corresponding":false},{"id":122726,"name":"Yixin Wu","orcid":null,"position":3,"is_corresponding":false},{"id":122727,"name":"Shahzad Munir","orcid":"0000-0002-0026-6007","position":4,"is_corresponding":false},{"id":122728,"name":"Yueqiu He","orcid":null,"position":5,"is_corresponding":false},{"id":122723,"name":"Min Huang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36555647","pmcid":"PMC9785288","openalex_id":"https://openalex.org/W4312210177","authors":[],"funders":[{"funder_name":"Key Program of Local Universities Joint Project of Yunnan Province","grant_id":"202101BA070001-140","title":null},{"funder_name":"Key Program of Local Universities Joint Project of Yunnan Province","grant_id":"202102AE090023","title":null}],"total_grants":2,"fwci":1.0498,"citation_percentile":0.81175293,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":3},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/23/24/16005/pdf?version=1671524109","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/23/24/16005/pdf?version=1671524109","host_type":"GOLD"},{"url":"https://www.mdpi.com/1422-0067/23/24/16005/pdf?version=1671524109","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/23/24/16005/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms232416005","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36555647","host_type":"repository"},{"url":"https://doaj.org/article/1f522d1ebe864156b47791d1d5b29fe7","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/ijms232416005","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9785288","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9785288","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9785288?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Plant Pathogenic Bacteria Studies","Antibiotic Resistance in Bacteria","Genomics and Phylogenetic Studies","Medicine","Environmental Science","Biology","Animals","Mice","Humans","Klebsiella pneumoniae","Virulence Factors","Zea mays","Klebsiella Infections","Virulence","Cross Infection"],"mesh_terms":["Animals","Zea mays","Cross Infection","Humans","Klebsiella Infections","Klebsiella pneumoniae","Virulence","Virulence Factors","Mice"],"keywords":["Pathogen","Biology","Virulence","Klebsiella pneumoniae","Human pathogen","Microbiology","Gene","Genetics","Escherichia coli","Genome","Novel genes","Klebsiella Pneumoniae Kpc4","Crossing-kingdom Pathogen","Virulence Prediction"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"gen"},{"name":"uniprot"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-02T14:51:47.281049Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}