{"doi":"10.3390/ijms232315275","title":"EPH/Ephrin-Targeting Treatment in Breast Cancer: A New Chapter in Breast Cancer Therapy","abstract":"<jats:p>Breast cancer (BC) is the most common malignant tumor in women. Erythropoietin-producing hepatocellular receptors (EPHs), receptor tyrosine kinases binding the membrane-bound proteins ephrins, are differentially expressed in BC, and correlate with carcinogenesis and tumor progression. With a view to examining available therapeutics targeting the EPH/ephrin system in BC, a literature review was conducted, using the MEDLINE, LIVIVO, and Google Scholar databases. EPHA2 is the most studied EPH/ephrin target in BC treatment. The targeting of EPHA2, EPHA10, EPHB4, ephrin-A2, ephrin-A4, as well as ephrin-B2 in BC cells or xenograft models is associated with apoptosis induction, tumor regression, anticancer immune response activation, and impaired cell motility. In conclusion, EPHs/ephrins seem to represent promising future treatment targets in BC.</jats:p>","journal":"International Journal of Molecular Sciences","year":2022,"id":618543,"datarank":0.44166584687496613,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.0,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1595767,"name":"Eleni Souferi-Chronopoulou","orcid":null,"position":1,"is_corresponding":false},{"id":1595768,"name":"Kleio Vrettou","orcid":null,"position":2,"is_corresponding":false},{"id":1595770,"name":"Constantinos Troungos","orcid":null,"position":3,"is_corresponding":false},{"id":1256557,"name":"Stamatios Theocharis","orcid":"0000-0002-0930-1657","position":4,"is_corresponding":false},{"id":1595766,"name":"Iason Psilopatis","orcid":"0000-0001-8516-6242","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"EPH/Ephrin-Targeting Treatment in Breast Cancer: A New Chapter in Breast Cancer Therapy","abstract":"<jats:p>Breast cancer (BC) is the most common malignant tumor in women. Erythropoietin-producing hepatocellular receptors (EPHs), receptor tyrosine kinases binding the membrane-bound proteins ephrins, are differentially expressed in BC, and correlate with carcinogenesis and tumor progression. With a view to examining available therapeutics targeting the EPH/ephrin system in BC, a literature review was conducted, using the MEDLINE, LIVIVO, and Google Scholar databases. EPHA2 is the most studied EPH/ephrin target in BC treatment. The targeting of EPHA2, EPHA10, EPHB4, ephrin-A2, ephrin-A4, as well as ephrin-B2 in BC cells or xenograft models is associated with apoptosis induction, tumor regression, anticancer immune response activation, and impaired cell motility. In conclusion, EPHs/ephrins seem to represent promising future treatment targets in BC.</jats:p>","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36499598","pmcid":"PMC9740341","openalex_id":"https://openalex.org/W4310675636","authors":[],"funders":[],"total_grants":0,"fwci":1.5635,"citation_percentile":0.82253379,"influential_citations":0,"citation_trend":[{"year":2023,"count":10},{"year":2024,"count":6},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/23/23/15275/pdf?version=1670068239","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/23/23/15275/pdf?version=1670068239","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/23/23/15275/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms232315275","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36499598","host_type":"repository"},{"url":"https://doaj.org/article/4332f9e94ed04ce2b03555448a721a0b","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/ijms232315275","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9740341","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9740341","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9740341?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Axon Guidance and Neuronal Signaling","HER2/EGFR in Cancer Research","Wnt/β-catenin signaling in development and cancer","Humans","Female","Ephrins","Receptors, Eph Family","Breast Neoplasms","Ephrin-B2","Protein Binding","Membrane Proteins"],"mesh_terms":["Breast Neoplasms","Female","Humans","Membrane Proteins","Protein Binding","Receptors, Eph Family","Ephrins","Ephrin-B2"],"keywords":["Erythropoietin-producing hepatocellular (Eph) receptor","Ephrin","EPH receptor A2","Cancer research","Breast cancer","Cancer","Receptor tyrosine kinase","Biology","Medicine","Receptor","Internal medicine","Treatment","Eph","Ephrin Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T04:40:32.475649Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}