{"doi":"10.3390/ijms23179867","title":"Absorption and Metabolism of the Natural Sweeteners Erythritol and Xylitol in Humans: A Dose-Ranging Study","abstract":"<jats:p>The natural sweeteners erythritol and xylitol might be helpful to reduce sugar consumption and therefore prevent obesity and diabetes. The aim of the present study was to determine the absorption and metabolization into erythronate of different concentrations of erythritol and xylitol. Seventeen healthy lean participants received intragastric solutions of 10, 25, or 50 g erythritol or 7, 17, or 35 g xylitol on three study days in a randomized order. The study was double blinded with respect to the doses administered. We assessed plasma concentrations of erythritol, xylitol, and erythronate at fixed time intervals after administration with gas chromatography-mass spectrometry. We found: (i) a dose-dependent and saturable absorption of erythritol, (ii) a very low absorption of xylitol, (iii) a dose-dependent metabolization of erythritol into erythronate, and (iv) no metabolization of xylitol into erythronate. The implications of the metabolization of erythritol into erythronate for human health remain to be determined and more research in this area is needed.</jats:p>","journal":"International Journal of Molecular Sciences","year":2022,"id":627229,"datarank":0.5050943744979712,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.0,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1582718,"name":"Fabienne Teysseire","orcid":"0000-0001-8602-9960","position":1,"is_corresponding":false},{"id":1622977,"name":"Frank Senner","orcid":null,"position":2,"is_corresponding":false},{"id":1622978,"name":"Götz Schlotterbeck","orcid":null,"position":3,"is_corresponding":false},{"id":1622979,"name":"Jürgen Drewe","orcid":"0000-0001-5178-7825","position":4,"is_corresponding":false},{"id":1582723,"name":"Christoph Beglinger","orcid":null,"position":5,"is_corresponding":false},{"id":1352655,"name":"Bettina K. 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The study was double blinded with respect to the doses administered. We assessed plasma concentrations of erythritol, xylitol, and erythronate at fixed time intervals after administration with gas chromatography-mass spectrometry. We found: (i) a dose-dependent and saturable absorption of erythritol, (ii) a very low absorption of xylitol, (iii) a dose-dependent metabolization of erythritol into erythronate, and (iv) no metabolization of xylitol into erythronate. The implications of the metabolization of erythritol into erythronate for human health remain to be determined and more research in this area is needed.</jats:p>","is_dataset_classified":null,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36077269","pmcid":"PMC9456049","openalex_id":"https://openalex.org/W4293773229","authors":[],"funders":[],"total_grants":0,"fwci":2.7834,"citation_percentile":0.91253102,"influential_citations":0,"citation_trend":[{"year":2023,"count":6},{"year":2024,"count":8},{"year":2025,"count":12},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/23/17/9867/pdf?version=1661999521","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/23/17/9867/pdf?version=1661999521","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/23/17/9867/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms23179867","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36077269","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/ijms23179867","host_type":"repository"},{"url":"https://doaj.org/article/bc2765af49bb45afac45a8e9c1cbf1c5","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9456049","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9456049","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9456049?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Biochemical Analysis and Sensing Techniques","Metabolomics and Mass Spectrometry Studies","Diet, Metabolism, and Disease","Diabetes Mellitus","Erythritol","Humans","Obesity","Sweetening Agents","Xylitol"],"mesh_terms":["Diabetes Mellitus","Erythritol","Humans","Obesity","Sweetening Agents","Xylitol"],"keywords":["Erythritol","Xylitol","Sugar alcohol","Polyol","Chemistry","Absorption (acoustics)","Food science","Biochemistry","Chromatography","Sugar","Fermentation","Materials science","Metabolism","Obesity","Absorption","Diabetes","Natural Sweeteners","Erythronate"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"nct"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-04T16:45:59.426549Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}