{"doi":"10.3390/ijms23168951","title":"Experiences of Trauma and DNA Methylation Profiles among African American Mothers and Children","abstract":"<jats:p>Potentially traumatic experiences have been associated with chronic diseases. Epigenetic mechanisms, including DNA methylation (DNAm), have been proposed as an explanation for this association. We examined the association of experiences of trauma with epigenome-wide DNAm among African American mothers (n = 236) and their children aged 3–5 years (n = 232; N = 500), using the Life Events Checklist-5 (LEC) and Traumatic Events Screening Inventory—Parent Report Revised (TESI-PRR). We identified no DNAm sites significantly associated with potentially traumatic experience scores in mothers. One CpG site on the ENOX1 gene was methylome-wide-significant in children (FDR-corrected q-value = 0.05) from the TESI-PRR. This protein-coding gene is associated with mental illness, including unipolar depression, bipolar, and schizophrenia. Future research should further examine the associations between childhood trauma, DNAm, and health outcomes among this understudied and high-risk group. Findings from such longitudinal research may inform clinical and translational approaches to prevent adverse health outcomes associated with epigenetic changes.</jats:p>","journal":"International Journal of Molecular Sciences","year":2022,"id":617260,"datarank":0.24223100876947545,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.03428685460149184,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.03428685460149184,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":251646,"name":"Yunfeng Huang","orcid":"0000-0003-2120-3328","position":1,"is_corresponding":false},{"id":644915,"name":"Billy A. Caceres","orcid":"0000-0001-6865-5546","position":2,"is_corresponding":false},{"id":873868,"name":"Kevin P. Newhall","orcid":"0000-0002-4226-718X","position":3,"is_corresponding":false},{"id":292478,"name":"Qin Hui","orcid":"0000-0002-8421-3518","position":4,"is_corresponding":false},{"id":228465,"name":"Jessica P. Cerdeña","orcid":"0000-0003-1317-116X","position":5,"is_corresponding":false},{"id":665903,"name":"Cindy A. Crusto","orcid":"0000-0003-3300-3040","position":6,"is_corresponding":false},{"id":22017,"name":"Yan V. Sun","orcid":"0000-0002-2838-1824","position":7,"is_corresponding":false},{"id":665904,"name":"Jacquelyn Y. Taylor","orcid":"0000-0002-0858-7358","position":8,"is_corresponding":false},{"id":665901,"name":"Veronica Barcelona","orcid":"0000-0003-3070-1716","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Experiences of Trauma and DNA Methylation Profiles among African American Mothers and Children","abstract":"<jats:p>Potentially traumatic experiences have been associated with chronic diseases. Epigenetic mechanisms, including DNA methylation (DNAm), have been proposed as an explanation for this association. We examined the association of experiences of trauma with epigenome-wide DNAm among African American mothers (n = 236) and their children aged 3–5 years (n = 232; N = 500), using the Life Events Checklist-5 (LEC) and Traumatic Events Screening Inventory—Parent Report Revised (TESI-PRR). We identified no DNAm sites significantly associated with potentially traumatic experience scores in mothers. One CpG site on the ENOX1 gene was methylome-wide-significant in children (FDR-corrected q-value = 0.05) from the TESI-PRR. This protein-coding gene is associated with mental illness, including unipolar depression, bipolar, and schizophrenia. Future research should further examine the associations between childhood trauma, DNAm, and health outcomes among this understudied and high-risk group. Findings from such longitudinal research may inform clinical and translational approaches to prevent adverse health outcomes associated with epigenetic changes.</jats:p>","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"36012217","pmcid":"PMC9408935","openalex_id":"https://openalex.org/W4290999246","authors":[],"funders":[{"funder_name":"National Institutes of Health, National Institute of Nursing Research","grant_id":"R01NR013520","title":null},{"funder_name":"National Institutes of Health, National Institute of Nursing Research","grant_id":"T32GM136651","title":null},{"funder_name":"Yale School of Nursing Alumni Donor","grant_id":"n/a","title":null},{"funder_name":"National Institutes of Health","grant_id":"7R01NR013520-08","title":"Intergenerational Impact of Genetic and Psychological Factors on Blood Pressure"},{"funder_name":"National Institutes of Health","grant_id":"3T32GM136651-02S2","title":"Medical Scientist Training Program"}],"total_grants":5,"fwci":0.8184,"citation_percentile":0.72955975,"influential_citations":0,"citation_trend":[{"year":2023,"count":1},{"year":2024,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/23/16/8951/pdf?version=1660213444","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/23/16/8951/pdf?version=1660213444","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/23/16/8951/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms23168951","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/36012217","host_type":"repository"},{"url":"https://doaj.org/article/0cd6eef00290467f89ad38cfb4a1e1d5","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/ijms23168951","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9408935","host_type":"repository"},{"url":"https://repository.up.ac.za/handle/2263/88776","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9408935","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9408935?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3390/ijms23168951","host_type":""},{"url":"https://doi.org/https://doi.org/10.3390/ijms23168951","host_type":""}],"fields_of_study":["Adolescent and Pediatric Healthcare","Child Abuse and Trauma","Child and Adolescent Health","03 medical and health sciences","0302 clinical medicine","Black or African American","Child","DNA Methylation","Epigenesis, Genetic","Epigenome","Epigenomics","Female","Humans","Mothers"],"mesh_terms":["Epigenome","Black or African American","Child","Female","Humans","Mothers","DNA Methylation","Epigenesis, Genetic","Epigenomics"],"keywords":["dNaM","DNA methylation","Epigenetics","Epigenome","CpG site","Depression (economics)","Medicine","Psychiatry","Biology","Genetics","Gene","Trauma","Women","epigenomics","African Americans","Aces","360","Adverse childhood experiences (ACES)","Mothers","Deoxyribonucleic acid (DNA)","Article","Epigenesis, Genetic","Black or African American","Humans","Female","Child"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. Good health"},{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T01:14:02.216246Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}