{"doi":"10.3390/ijms23147983","title":"Proteomic Biomarkers of the Apnea Hypopnea Index and Obstructive Sleep Apnea: Insights into the Pathophysiology of Presence, Severity, and Treatment Response","abstract":"Obstructive sleep apnea (OSA), a disease associated with excessive sleepiness and increased cardiovascular risk, affects an estimated 1 billion people worldwide. The present study examined proteomic biomarkers indicative of presence, severity, and treatment response in OSA. Participants (n = 1391) of the Stanford Technology Analytics and Genomics in Sleep study had blood collected and completed an overnight polysomnography for scoring the apnea−hypopnea index (AHI). A highly multiplexed aptamer-based array (SomaScan) was used to quantify 5000 proteins in all plasma samples. Two separate intervention-based cohorts with sleep apnea (n = 41) provided samples pre- and post-continuous/positive airway pressure (CPAP/PAP). Multivariate analyses identified 84 proteins (47 positively, 37 negatively) associated with AHI after correction for multiple testing. Of the top 15 features from a machine learning classifier for AHI ≥ 15 vs. AHI < 15 (Area Under the Curve (AUC) = 0.74), 8 were significant markers of both AHI and OSA from multivariate analyses. Exploration of pre- and post-intervention analysis identified 5 of the 84 proteins to be significantly decreased following CPAP/PAP treatment, with pathways involving endothelial function, blood coagulation, and inflammatory response. The present study identified PAI-1, tPA, and sE-Selectin as key biomarkers and suggests that endothelial dysfunction and increased coagulopathy are important consequences of OSA, which may explain the association with cardiovascular disease and stroke.","journal":"International Journal of Molecular Sciences","year":2022,"id":244411,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":29,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7933,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":688359,"name":"Umaer Hanif","orcid":"0000-0001-8288-5532","position":1,"is_corresponding":false},{"id":487370,"name":"Vicente Peris Sempere","orcid":null,"position":2,"is_corresponding":false},{"id":271982,"name":"Julien Hédou","orcid":"0000-0003-4721-4797","position":3,"is_corresponding":false},{"id":481393,"name":"Eileen Leary","orcid":"0000-0002-7389-6384","position":4,"is_corresponding":false},{"id":431856,"name":"Logan Schneider","orcid":"0000-0001-8729-5224","position":5,"is_corresponding":false},{"id":486037,"name":"Ling Lin","orcid":"0000-0002-3406-0058","position":6,"is_corresponding":false},{"id":638977,"name":"Jing Zhang","orcid":"0000-0002-6566-6693","position":7,"is_corresponding":false},{"id":688360,"name":"Anne Marie Morse","orcid":"0000-0003-4494-0195","position":8,"is_corresponding":false},{"id":688361,"name":"Adam Blackman","orcid":"0000-0003-0467-040X","position":9,"is_corresponding":false},{"id":688845,"name":"Paula K. Schweitzer","orcid":null,"position":10,"is_corresponding":false},{"id":490229,"name":"Suresh Kotagal","orcid":"0000-0002-8614-371X","position":11,"is_corresponding":false},{"id":877730,"name":"Richard Bogan","orcid":"0000-0001-7043-2974","position":12,"is_corresponding":false},{"id":688362,"name":"Clete A. Kushida","orcid":"0000-0002-9430-3752","position":13,"is_corresponding":false},{"id":284801,"name":"Yo‐El S. Ju","orcid":"0000-0001-9397-7475","position":14,"is_corresponding":false},{"id":624106,"name":"Nayia Petousi","orcid":"0000-0002-5524-020X","position":15,"is_corresponding":false},{"id":829171,"name":"Chris D. Turnbull","orcid":"0000-0001-8942-5424","position":16,"is_corresponding":false},{"id":57704,"name":"Emmanuel Mignot","orcid":"0000-0002-6928-5310","position":17,"is_corresponding":false},{"id":878150,"name":"The STAGES Cohort Investigator Group","orcid":null,"position":18,"is_corresponding":false},{"id":441737,"name":"Katie L.J. Cederberg","orcid":"0000-0001-5693-9293","position":0,"is_corresponding":true}],"reference_count":54,"raw_metadata":null,"created_at":"2026-07-19T00:23:25.718788Z","pmid":"35887329","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}