{"doi":"10.3390/ijms23147843","title":"Applications of Circulating Tumor Cells and Circulating Tumor DNA in Precision Oncology for Breast Cancers","abstract":"<jats:p>Liquid biopsies allow for the detection of cancer biomarkers such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). Elevated levels of these biomarkers during cancer treatment could potentially serve as indicators of cancer progression and shed light on the mechanisms of metastasis and therapy resistance. Thus, liquid biopsies serve as tools for cancer detection and monitoring through a simple, non-invasive blood draw, allowing multiple longitudinal sampling. These circulating markers have significant prospects for use in assessing patients’ prognosis, monitoring response to therapy, and developing precision medicine. In addition, single-cell omics of these liquid biopsy markers can be potential tools for identifying tumor heterogeneity and plasticity as well as novel therapeutic targets. In this review, we focus on our current understanding of circulating tumor biomarkers, especially in breast cancer, and the scope of novel sequencing technologies and diagnostic methods for better prognostication and patient stratification to improve patient outcomes.</jats:p>","journal":"International Journal of Molecular Sciences","year":2022,"id":104947,"datarank":1.339190280308249,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.7785398375657435,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.7785398375657435,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":40,"citers_with_citation_signal":30,"citers_with_endowment":30,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":509486,"name":"Salyna Meas","orcid":null,"position":1,"is_corresponding":false},{"id":509488,"name":"Vanessa Nicole Sarli","orcid":null,"position":2,"is_corresponding":false},{"id":509489,"name":"Balraj Singh","orcid":"0000-0002-2985-5884","position":3,"is_corresponding":false},{"id":104285,"name":"Anthony Lucci","orcid":"0000-0003-4039-174X","position":4,"is_corresponding":false},{"id":237234,"name":"Sridevi Addanki","orcid":"0000-0002-9224-3813","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Applications of Circulating Tumor Cells and Circulating Tumor DNA in Precision Oncology for Breast Cancers","abstract":"<jats:p>Liquid biopsies allow for the detection of cancer biomarkers such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA). Elevated levels of these biomarkers during cancer treatment could potentially serve as indicators of cancer progression and shed light on the mechanisms of metastasis and therapy resistance. Thus, liquid biopsies serve as tools for cancer detection and monitoring through a simple, non-invasive blood draw, allowing multiple longitudinal sampling. These circulating markers have significant prospects for use in assessing patients’ prognosis, monitoring response to therapy, and developing precision medicine. In addition, single-cell omics of these liquid biopsy markers can be potential tools for identifying tumor heterogeneity and plasticity as well as novel therapeutic targets. In this review, we focus on our current understanding of circulating tumor biomarkers, especially in breast cancer, and the scope of novel sequencing technologies and diagnostic methods for better prognostication and patient stratification to improve patient outcomes.</jats:p>","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35887191","pmcid":"PMC9315812","openalex_id":"https://openalex.org/W4285732649","authors":[],"funders":[{"funder_name":"Sheila Abrams Prenowitz and Donald Morton Prenowitz Endowment Fund","grant_id":"","title":null},{"funder_name":"State of Texas Rare and Aggressive Breast Cancer Research Program","grant_id":"","title":null},{"funder_name":"Wintermann Foundation","grant_id":"","title":null}],"total_grants":3,"fwci":2.9424,"citation_percentile":0.93264904,"influential_citations":1,"citation_trend":[{"year":2022,"count":4},{"year":2023,"count":11},{"year":2024,"count":11},{"year":2025,"count":9},{"year":2026,"count":6}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/23/14/7843/pdf?version=1657961322","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/23/14/7843/pdf?version=1657961322","host_type":"GOLD"},{"url":"https://www.mdpi.com/1422-0067/23/14/7843/pdf?version=1657961322","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/23/14/7843/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms23147843","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35887191","host_type":"repository"},{"url":"https://doaj.org/article/3ea2bd9608c0407a94bf1d772393a047","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/ijms23147843","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9315812","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9315812","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9315812?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Cancer Genomics and Diagnostics","Cancer Cells and Metastasis","Single-cell and spatial transcriptomics","Medicine","Biomarkers, Tumor","Breast Neoplasms","Circulating Tumor DNA","Female","Humans","Liquid Biopsy","Neoplastic Cells, Circulating","Precision Medicine"],"mesh_terms":["Liquid Biopsy","Circulating Tumor DNA","Breast Neoplasms","Female","Humans","Neoplastic Cells, Circulating","Biomarkers, Tumor","Precision Medicine"],"keywords":["Circulating tumor cell","Liquid biopsy","Precision medicine","Breast cancer","Medicine","Circulating tumor DNA","Cancer","Personalized medicine","Biomarker","Oncology","Metastasis","Cell-free fetal DNA","Internal medicine","Cancer research","Bioinformatics","Pathology","Biology","Screening","Diagnosis","Next Generation Sequencing","Circulating Tumor Cells","Early Stage Breast Cancer","Late-stage Breast Cancer"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-18T22:50:02.402278Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}