{"doi":"10.3390/ijms23137365","title":"Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2","abstract":"<jats:p>Virus–cell fusion is the key step for viral infection in host cells. Studies on virus binding and fusion with host cells are important for understanding the virus–host interaction and viral pathogenesis for the discovery of antiviral drugs. In this review, we focus on the virus–cell fusions induced by the two major pandemic viruses, including the influenza virus and SARS-CoV-2. We further compare the cell fusions induced by the influenza virus and SARS-CoV-2, especially the pH-dependent fusion of the influenza virus and the fusion of SARS-CoV-2 in the type-II transmembrane serine protease 2 negative (TMPRSS2-) cells with syncytia formation. Finally, we present the development of drugs used against SARA-CoV-2 and the influenza virus through the discovery of anti-fusion drugs and the prevention of pandemic respiratory viruses.</jats:p>","journal":"International Journal of Molecular Sciences","year":2022,"id":622961,"datarank":0.29188652235829704,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"self_citation_contribution":0.29188652235829704,"citation_network_contribution":0.0,"self_endowment_contribution":0.29188652235829704,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1609835,"name":"Xinjie Meng","orcid":null,"position":1,"is_corresponding":false},{"id":1609836,"name":"Hanjun Zhao","orcid":null,"position":2,"is_corresponding":false},{"id":1609834,"name":"Chuyuan Zhang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Comparison of Cell Fusions Induced by Influenza Virus and SARS-CoV-2","abstract":"<jats:p>Virus–cell fusion is the key step for viral infection in host cells. Studies on virus binding and fusion with host cells are important for understanding the virus–host interaction and viral pathogenesis for the discovery of antiviral drugs. In this review, we focus on the virus–cell fusions induced by the two major pandemic viruses, including the influenza virus and SARS-CoV-2. We further compare the cell fusions induced by the influenza virus and SARS-CoV-2, especially the pH-dependent fusion of the influenza virus and the fusion of SARS-CoV-2 in the type-II transmembrane serine protease 2 negative (TMPRSS2-) cells with syncytia formation. Finally, we present the development of drugs used against SARA-CoV-2 and the influenza virus through the discovery of anti-fusion drugs and the prevention of pandemic respiratory viruses.</jats:p>","is_dataset_classified":null,"base_score":1.9459101490553132,"endowment":1.9459101490553132,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35806369","pmcid":"PMC9266613","openalex_id":"https://openalex.org/W4283802257","authors":[],"funders":[{"funder_name":"National Program on Key Research Project of China","grant_id":"2020YFA0707500","title":null},{"funder_name":"National Program on Key Research Project of China","grant_id":"2020YFA0707504","title":null},{"funder_name":"National Program on Key Research Project of China","grant_id":"T11-709/21-N","title":null},{"funder_name":"National Program on Key Research Project of China","grant_id":"COVID1903010-Project 13","title":null},{"funder_name":"Health@InnoHK, Innovation and Technology Commission, the Government of the Hong Kong Special Administrative Region, China","grant_id":"","title":null}],"total_grants":5,"fwci":0.4402,"citation_percentile":0.6039493,"influential_citations":0,"citation_trend":[{"year":2023,"count":2},{"year":2024,"count":1},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/23/13/7365/pdf?version=1657000254","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/23/13/7365/pdf?version=1657000254","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/23/13/7365/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms23137365","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35806369","host_type":"repository"},{"url":"https://doaj.org/article/d7ee5ce73920478883e14b3c3798f5d6","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/ijms23137365","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9266613","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9266613","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9266613?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Influenza Virus Research Studies","Respiratory viral infections research","SARS-CoV-2 and COVID-19 Research"],"mesh_terms":["COVID-19","SARS-CoV-2","Cell Fusion","Humans","Orthomyxoviridae","Virus Internalization","Spike Glycoprotein, Coronavirus"],"keywords":["Virology","Virus","Biology","TMPRSS2","Influenza A virus","Viral entry","Cell fusion","Syncytium","Lipid bilayer fusion","Viral culture","Cell culture","Viral replication","Coronavirus disease 2019 (COVID-19)","Medicine","Genetics","Influenza Virus","Fusion inhibitors","Cell Fusions","Sars-cov-2"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T21:44:19.549345Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}