{"doi":"10.3390/ijms23136939","title":"Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway","abstract":"<jats:p>TLR4/NF-κB is a key inflammatory signaling transduction pathway, closely involved in cell differentiation, proliferation, apoptosis, and pro-inflammatory response. Toll like receptor 4 (TLR4), the first mammalian TLR to be characterized, is the innate immune receptor that plays a key role in inflammatory signal transductions. Nuclear factor kappa B (NF-κB), the TLR4 downstream, is the key to accounting for the expression of multiple genes involved in inflammatory responses, such as pro-inflammatory cytokines. Inflammatory bowel disease (IBD) in humans is a chronic inflammatory disease with high incidence and prevalence worldwide. Targeting the TLR4/NF-κB signaling pathway might be an effective strategy to alleviate intestinal inflammation. Polyphenol phytochemicals have shown noticeable alleviative effects by acting on the TLR4/NF-κB signaling pathway in intestinal inflammation. This review summarizes the pharmacological effects of more than 20 kinds of polyphenols on intestinal inflammation via targeting the TLR4/NF-κB signaling pathway. We expected that polyphenol phytochemicals targeting the TLR4/NF-κB signaling pathway might be an effective approach to treat IBD in future clinical research applications.</jats:p>","journal":"International Journal of Molecular Sciences","year":2022,"id":620898,"datarank":0.7515952941144385,"base_score":5.0106352940962555,"endowment":5.0106352940962555,"self_citation_contribution":0.7515952941144385,"citation_network_contribution":0.0,"self_endowment_contribution":0.7515952941144385,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":149,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":761966,"name":"Dong Wang","orcid":"0000-0002-8139-8502","position":1,"is_corresponding":false},{"id":1603025,"name":"Zaibin Yang","orcid":null,"position":2,"is_corresponding":false},{"id":1022979,"name":"Tian Wang","orcid":"0000-0001-7365-7423","position":3,"is_corresponding":false},{"id":1511587,"name":"Caiyun Yu","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Pharmacological Effects of Polyphenol Phytochemicals on the Intestinal Inflammation via Targeting TLR4/NF-κB Signaling Pathway","abstract":"<jats:p>TLR4/NF-κB is a key inflammatory signaling transduction pathway, closely involved in cell differentiation, proliferation, apoptosis, and pro-inflammatory response. Toll like receptor 4 (TLR4), the first mammalian TLR to be characterized, is the innate immune receptor that plays a key role in inflammatory signal transductions. Nuclear factor kappa B (NF-κB), the TLR4 downstream, is the key to accounting for the expression of multiple genes involved in inflammatory responses, such as pro-inflammatory cytokines. Inflammatory bowel disease (IBD) in humans is a chronic inflammatory disease with high incidence and prevalence worldwide. Targeting the TLR4/NF-κB signaling pathway might be an effective strategy to alleviate intestinal inflammation. Polyphenol phytochemicals have shown noticeable alleviative effects by acting on the TLR4/NF-κB signaling pathway in intestinal inflammation. This review summarizes the pharmacological effects of more than 20 kinds of polyphenols on intestinal inflammation via targeting the TLR4/NF-κB signaling pathway. We expected that polyphenol phytochemicals targeting the TLR4/NF-κB signaling pathway might be an effective approach to treat IBD in future clinical research applications.</jats:p>","is_dataset_classified":null,"base_score":5.0106352940962555,"endowment":5.0106352940962555,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"35805952","pmcid":"PMC9266441","openalex_id":"https://openalex.org/W4283326295","authors":[],"funders":[{"funder_name":"Tian Wang","grant_id":"2018YFD0501101","title":null}],"total_grants":1,"fwci":19.1619,"citation_percentile":0.99567996,"influential_citations":0,"citation_trend":[{"year":2022,"count":3},{"year":2023,"count":18},{"year":2024,"count":36},{"year":2025,"count":57},{"year":2026,"count":35}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/23/13/6939/pdf?version=1656061309","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/23/13/6939/pdf?version=1656061309","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/23/13/6939/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms23136939","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/35805952","host_type":"repository"},{"url":"https://doaj.org/article/1b08a17a7c244484950c314f05697d33","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/ijms23136939","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/9266441","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC9266441","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC9266441?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Inflammatory Bowel Disease","Pharmacological Effects of Medicinal Plants","Helicobacter pylori-related gastroenterology studies","Animals","Humans","Inflammation","Inflammatory Bowel Diseases","Intestines","Mice","NF-kappa B","Polyphenols","Rats","Signal Transduction","Toll-Like Receptor 4"],"mesh_terms":["Animals","Humans","Inflammation","Intestines","Inflammatory Bowel Diseases","Signal Transduction","NF-kappa B","Toll-Like Receptor 4","Mice","Rats","Polyphenols"],"keywords":["TLR4","Signal transduction","Inflammation","NF-κB","Toll-like receptor","Inflammatory bowel disease","Biology","Cancer research","NFKB1","Immunology","Innate immune system","Cell biology","Medicine","Immune system","Transcription factor","Disease","Biochemistry","Internal medicine","Gene","Polyphenols","Intestinal Inflammation","Tlr4/nf-κb Signaling Pathway"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-03T12:30:07.790686Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}