{"doi":"10.3390/ijms23094887","title":"NAD+ Precursors Repair Mitochondrial Function in Diabetes and Prevent Experimental Diabetic Neuropathy","abstract":"Axon degeneration in diabetic peripheral neuropathy (DPN) is associated with impaired NAD+ metabolism. We tested whether the administration of NAD+ precursors, nicotinamide mononucleotide (NMN) or nicotinamide riboside (NR), prevents DPN in models of Type 1 and Type 2 diabetes. NMN was administered to streptozotocin (STZ)-induced diabetic rats and STZ-induced diabetic mice by intraperitoneal injection at 50 or 100 mg/kg on alternate days for 2 months. mice The were fed with a high fat diet (HFD) for 2 months with or without added NR at 150 or 300 mg/kg for 2 months. The administration of NMN to STZ-induced diabetic rats or mice or dietary addition of NR to HFD-fed mice improved sensory function, normalized sciatic and tail nerve conduction velocities, and prevented loss of intraepidermal nerve fibers in skin samples from the hind-paw. In adult dorsal root ganglion (DRG) neurons isolated from HFD-fed mice, there was a decrease in NAD+ levels and mitochondrial maximum reserve capacity. These impairments were normalized in isolated DRG neurons from NR-treated mice. The results indicate that the correction of NAD+ depletion in DRG may be sufficient to prevent DPN but does not significantly affect glucose tolerance, insulin levels, or insulin resistance.","journal":"International Journal of Molecular Sciences","year":2022,"id":243071,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":35,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9583,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":875488,"name":"Neda Najimi","orcid":null,"position":1,"is_corresponding":false},{"id":875489,"name":"Avinash R. Sagi","orcid":null,"position":2,"is_corresponding":false},{"id":874774,"name":"Sushuma Yarlagadda","orcid":"0000-0001-6489-3854","position":3,"is_corresponding":false},{"id":296696,"name":"Mohammad Salimian","orcid":null,"position":4,"is_corresponding":false},{"id":296695,"name":"Muhammed Ikbal Arvas","orcid":null,"position":5,"is_corresponding":false},{"id":334645,"name":"Ahmad F. Hedayat","orcid":"0000-0001-9248-5022","position":6,"is_corresponding":false},{"id":875490,"name":"Yanni Kevas","orcid":null,"position":7,"is_corresponding":false},{"id":875491,"name":"Anand Kadakia","orcid":null,"position":8,"is_corresponding":false},{"id":292142,"name":"James W. Russell","orcid":"0000-0002-8940-8920","position":9,"is_corresponding":false},{"id":294917,"name":"Krish Chandrasekaran","orcid":"0000-0003-3434-2394","position":0,"is_corresponding":true}],"reference_count":81,"raw_metadata":null,"created_at":"2026-07-19T00:23:16.032700Z","pmid":"35563288","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}