{"doi":"10.3390/ijms23062950","title":"2-Aminoimidazoles Inhibit Mycobacterium abscessus Biofilms in a Zinc-Dependent Manner","abstract":"Biofilm growth is thought to be a significant obstacle to the successful treatment of Mycobacterium abscessus infections. A search for agents capable of inhibiting M. abscessus biofilms led to our interest in 2-aminoimidazoles and related scaffolds, which have proven to display antibiofilm properties against a number of Gram-negative and Gram-positive bacteria, including Mycobacterium tuberculosis and Mycobacterium smegmatis. The screening of a library of 30 compounds led to the identification of a compound, AB-2-29, which inhibits the formation of M. abscessus biofilms with an IC50 (the concentration required to inhibit 50% of biofilm formation) in the range of 12.5 to 25 μM. Interestingly, AB-2-29 appears to chelate zinc, and its antibiofilm activity is potentiated by the addition of zinc to the culture medium. Preliminary mechanistic studies indicate that AB-2-29 acts through a distinct mechanism from those reported to date for 2-aminoimidazole compounds.","journal":"International Journal of Molecular Sciences","year":2022,"id":273806,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9522,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":242355,"name":"Wěi Li","orcid":"0000-0002-9522-4474","position":1,"is_corresponding":false},{"id":671921,"name":"Kevin H. Martin","orcid":"0000-0003-0751-4082","position":2,"is_corresponding":false},{"id":416563,"name":"Michael J. Zeiler","orcid":"0009-0001-0454-342X","position":3,"is_corresponding":false},{"id":671919,"name":"Elena Lian","orcid":"0000-0003-3344-6407","position":4,"is_corresponding":false},{"id":398086,"name":"Charlotte Avanzi","orcid":"0000-0002-1062-4058","position":5,"is_corresponding":false},{"id":672979,"name":"Crystal J. Wiersma","orcid":null,"position":6,"is_corresponding":false},{"id":941799,"name":"Tuan Vu Nguyen","orcid":null,"position":7,"is_corresponding":false},{"id":541266,"name":"Bhanupriya Angala","orcid":null,"position":8,"is_corresponding":false},{"id":671922,"name":"Vinicius Calado Nogueira de Moura","orcid":"0000-0001-5874-0958","position":9,"is_corresponding":false},{"id":671923,"name":"Victoria Jones","orcid":"0000-0001-8232-6124","position":10,"is_corresponding":false},{"id":671925,"name":"Bradley R. Borlee","orcid":"0000-0002-6321-2014","position":11,"is_corresponding":false},{"id":258371,"name":"Christian Melander","orcid":"0000-0001-8271-4696","position":12,"is_corresponding":false},{"id":363356,"name":"Mary Jackson","orcid":"0000-0002-9212-0258","position":13,"is_corresponding":false},{"id":435691,"name":"Juan M. Belardinelli","orcid":"0000-0003-1336-9141","position":0,"is_corresponding":true}],"reference_count":49,"raw_metadata":null,"created_at":"2026-07-19T00:28:03.504676Z","pmid":"35328372","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}