{"doi":"10.3390/ijms23052732","title":"Using VBIM Technique to Discover ARMC4/ODAD2 as a Novel Negative Regulator of NF-κB and a New Tumor Suppressor in Colorectal Cancer","abstract":"Since nuclear factor (NF) κB plays pivotal roles in inflammation and cancer, understanding its regulation holds great promise for disease therapy. Using the powerful validation-based insertional mutagenesis (VBIM) technique established by us previously, we discovered armadillo repeat-containing protein 4 (ARMC4)/outer dynein arm docking complex subunit 2 (ODAD2), a rarely studied protein known to date, as a novel negative regulator of NF-κB in colorectal cancer (CRC). High expression of ARMC4 downregulated the expression of NF-κB-dependent genes, dramatically reduced NF-κB activity, cellular proliferation, anchorage-independent growth, and migratory ability in vitro, and significantly decreased xenograft tumor growth in vivo. Co-immunoprecipitation experiments demonstrated that ARMC4 forms a complex with NF-κB. Importantly, the lower ARMC4 expression in patient tumors than normal tissues indicates its potential tumor suppressor function in CRC. Collectively, we uncovered a completely new facet of ARMC4 function by identifying it as a novel NF-κB negative regulator, thus uncovering ARMC4 as a potential new therapeutic target in CRC.","journal":"International Journal of Molecular Sciences","year":2022,"id":272492,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.959,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":293632,"name":"Rasika Mundade","orcid":null,"position":1,"is_corresponding":false},{"id":292112,"name":"Antja-Voy Hartley","orcid":"0000-0002-5934-5885","position":2,"is_corresponding":false},{"id":292113,"name":"Guanglong Jiang","orcid":"0000-0002-9233-052X","position":3,"is_corresponding":false},{"id":912348,"name":"Jiamin Jin","orcid":"0000-0001-9141-3350","position":4,"is_corresponding":false},{"id":292116,"name":"Steven Sun","orcid":"0000-0002-0173-3762","position":5,"is_corresponding":false},{"id":470623,"name":"Ahmad R. Safa","orcid":null,"position":6,"is_corresponding":false},{"id":314339,"name":"George E. Sandusky","orcid":"0000-0003-0769-057X","position":7,"is_corresponding":false},{"id":227678,"name":"Yunlong Liu","orcid":"0000-0002-2699-626X","position":8,"is_corresponding":false},{"id":292117,"name":"Tao Lu","orcid":"0000-0002-0013-4987","position":9,"is_corresponding":false},{"id":465315,"name":"Matthew Martin","orcid":"0000-0002-3961-5809","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T00:27:47.926496Z","pmid":"35269880","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}