{"doi":"10.3390/ijms222413204","title":"Ribosome Fate during Decoding of UGA-Sec Codons","abstract":"<jats:p>Decoding of genetic information into polypeptides occurs during translation, generally following the codon assignment rules of the organism’s genetic code. However, recoding signals in certain mRNAs can overwrite the normal rules of translation. An exquisite example of this occurs during translation of selenoprotein mRNAs, wherein UGA codons are reassigned to encode for the 21st proteogenic amino acid, selenocysteine. In this review, we will examine what is known about the mechanisms of UGA recoding and discuss the fate of ribosomes that fail to incorporate selenocysteine.</jats:p>","journal":"International Journal of Molecular Sciences","year":2021,"id":34801,"datarank":0.5746414288592233,"base_score":2.639057329615259,"endowment":2.639057329615259,"self_citation_contribution":0.3958585994422889,"citation_network_contribution":0.17878282941693444,"self_endowment_contribution":0.3958585994422889,"citer_contribution":0.17878282941693444,"corpus_percentile":null,"corpus_rank":null,"citation_count":13,"citer_count":13,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":179569,"name":"Michael T. Howard","orcid":null,"position":1,"is_corresponding":false},{"id":179568,"name":"Paul R. Copeland","orcid":"0000-0003-3343-0587","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.639057329615259,"endowment":2.639057329615259,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34948001","pmcid":"PMC8704476","openalex_id":"https://openalex.org/W4200612856","authors":[],"funders":[{"funder_name":"National Institute of General Medical Sciences","grant_id":"R01GM077073","title":null},{"funder_name":"National Institute of General Medical Sciences","grant_id":"R01GM114291","title":null},{"funder_name":"National Institutes of Health","grant_id":"5R01GM077073-06","title":"Functional analysis of SBP2 and selenocysteine incorporation"},{"funder_name":"National Institutes of Health","grant_id":"5R01GM114291-03","title":"The effects of dietary selenium on translational control of protein synthesis"}],"total_grants":4,"fwci":0.8308,"citation_percentile":0.70926017,"influential_citations":1,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":3},{"year":2025,"count":3},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/22/24/13204/pdf?version=1638942846","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/22/24/13204/pdf?version=1638942846","host_type":"GOLD"},{"url":"https://www.mdpi.com/1422-0067/22/24/13204/pdf?version=1638942846","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/22/24/13204/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms222413204","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34948001","host_type":"repository"},{"url":"https://doaj.org/article/d670704c8f7445b69cc005b1c6a8d510","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/ijms222413204","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8704476","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8704476","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8704476?pdf=render","host_type":"Europe_PMC"},{"url":"http://dx.doi.org/10.3390/ijms222413204","host_type":""}],"fields_of_study":["Trace Elements in Health","Selenium in Biological Systems","RNA modifications and cancer","Medicine","Biology","0301 basic medicine","0303 health sciences","03 medical and health sciences"],"mesh_terms":["Animals","Genetic Code","Humans","Ribosomes","Protein Biosynthesis","Selenocysteine","Codon, Terminator","Selenoproteins"],"keywords":["Selenocysteine","Genetic code","Ribosome","Selenoprotein","Translation (biology)","Genetics","Stop codon","Computational biology","Biology","Amino acid","Gene","Messenger RNA","RNA","Biochemistry","Nonsense-mediated Decay","Recoding","Translation Termination","Ribosome Rescue","Secis-binding Protein","Secis","Protein Biosynthesis","Codon, Terminator","Animals","Humans","Review","Selenoproteins","Ribosomes"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T20:20:11.186032Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}