{"doi":"10.3390/ijms222111371","title":"NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond","abstract":"<jats:p>The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic aneurysm. Cardiovascular remodeling entails interrelated cellular processes (proliferation, survival/apoptosis, inflammation, extracellular matrix (ECM) synthesis/degradation, redox homeostasis, etc.) coordinately regulated by a reduced number of transcription factors. Nuclear receptors of the subfamily 4 group A (NR4A) have recently emerged as key master genes in multiple cellular processes and vital functions of different organs, and have been involved in a variety of high-incidence human pathologies including atherosclerosis and other CVDs. This paper reviews the major findings involving NR4A3 (Neuron-derived Orphan Receptor 1, NOR-1) in the cardiovascular remodeling operating in these diseases.</jats:p>","journal":"International Journal of Molecular Sciences","year":2021,"id":651312,"datarank":0.5837730447165941,"base_score":3.8918202981106265,"endowment":3.8918202981106265,"self_citation_contribution":0.5837730447165941,"citation_network_contribution":0.0,"self_endowment_contribution":0.5837730447165941,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":48,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1698540,"name":"Laia Cañes","orcid":null,"position":1,"is_corresponding":false},{"id":1648112,"name":"Judith Alonso","orcid":null,"position":2,"is_corresponding":false},{"id":1698541,"name":"Carme Ballester-Servera","orcid":null,"position":3,"is_corresponding":false},{"id":1273138,"name":"Antonio Rodríguez‐Sinovas","orcid":"0000-0003-2930-8773","position":4,"is_corresponding":false},{"id":1579610,"name":"Irene Corrales","orcid":null,"position":5,"is_corresponding":false},{"id":911212,"name":"Cristina Rodrı́guez","orcid":"0000-0002-6472-5647","position":6,"is_corresponding":false},{"id":911213,"name":"José Martínez‐González","orcid":"0000-0002-3894-7166","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"NR4A3: A Key Nuclear Receptor in Vascular Biology, Cardiovascular Remodeling, and Beyond.","abstract":"The mechanisms committed in the activation and response of vascular and inflammatory immune cells play a major role in tissue remodeling in cardiovascular diseases (CVDs) such as atherosclerosis, pulmonary arterial hypertension, and abdominal aortic aneurysm. Cardiovascular remodeling entails interrelated cellular processes (proliferation, survival/apoptosis, inflammation, extracellular matrix (ECM) synthesis/degradation, redox homeostasis, etc.) coordinately regulated by a reduced number of transcription factors. Nuclear receptors of the subfamily 4 group A (NR4A) have recently emerged as key master genes in multiple cellular processes and vital functions of different organs, and have been involved in a variety of high-incidence human pathologies including atherosclerosis and other CVDs. This paper reviews the major findings involving NR4A3 (Neuron-derived Orphan Receptor 1, NOR-1) in the cardiovascular remodeling operating in these diseases.","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34768801","pmcid":"PMC8583700","openalex_id":null,"authors":[],"funders":[{"funder_name":"Agència de Gestió d’Ajuts Universitaris i de Recerca","grant_id":"2017-SGR-00333","title":null},{"funder_name":"Ministerio de Ciencia e Innovacion","grant_id":"RTI2018-094727-B-100","title":null},{"funder_name":"Instituto de Salud Carlos III","grant_id":"PI20/01649","title":null},{"funder_name":"Ministerio de Universidades","grant_id":"FPU fellowship","title":null},{"funder_name":"Instituto de Salud Carlos III","grant_id":"PI18/0919","title":null}],"total_grants":5,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":null,"license":null,"oa_locations":[{"url":"https://europepmc.org/articles/PMC8583700","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8583700?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":[],"mesh_terms":["Cardiovascular System","Animals","Humans","Cardiovascular Diseases","Inflammation","DNA-Binding Proteins","Receptors, Thyroid Hormone","Nerve Tissue Proteins","Receptors, Steroid","Atherosclerosis","Atrial Remodeling","Pulmonary Arterial Hypertension"],"keywords":["Atherosclerosis","Abdominal aortic aneurysm","Nor-1","Cardiovascular Remodeling"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T07:25:34.899858Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}