{"doi":"10.3390/ijms222011255","title":"Multi-Omics Analysis of Gut Microbiota in Inflammatory Bowel Diseases: What Benefits for Diagnostic, Prognostic and Therapeutic Tools?","abstract":"<jats:p>Inflammatory bowel diseases (IBDs), which include Crohn’s disease and ulcerative colitis, are multifactorial diseases that involve in particular a modification of the gut microbiota, known as dysbiosis. The initial sets of metataxonomic and metagenomic data first made it possible to approximate the microbiota profile in IBD. In addition, today the new ‘omics’ techniques have enabled us to draw up a functional and integrative map of the microbiota. The key concern in IBD is to develop biomarkers that allow us to assess the activity of the disease and predict the complications and progression, while also guiding the therapeutic care so as to develop personalized medicine. In this review, we present all of the latest discoveries on the microbiota provided by “omics” and we outline the benefits of these techniques in developing new diagnostic, prognostic and therapeutic tools.</jats:p>","journal":"International Journal of Molecular Sciences","year":2021,"id":637368,"datarank":0.5676284450877392,"base_score":3.784189633918261,"endowment":3.784189633918261,"self_citation_contribution":0.5676284450877392,"citation_network_contribution":0.0,"self_endowment_contribution":0.5676284450877392,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":43,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1654919,"name":"Alexis Cassard","orcid":null,"position":1,"is_corresponding":false},{"id":1475517,"name":"Emmanuel Mas","orcid":"0000-0001-5425-7352","position":2,"is_corresponding":false},{"id":1475518,"name":"Frédérick Barreau","orcid":"0000-0002-7150-9619","position":3,"is_corresponding":false},{"id":1654917,"name":"Vickie Lacroix","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Multi-Omics Analysis of Gut Microbiota in Inflammatory Bowel Diseases: What Benefits for Diagnostic, Prognostic and Therapeutic Tools?","abstract":"<jats:p>Inflammatory bowel diseases (IBDs), which include Crohn’s disease and ulcerative colitis, are multifactorial diseases that involve in particular a modification of the gut microbiota, known as dysbiosis. The initial sets of metataxonomic and metagenomic data first made it possible to approximate the microbiota profile in IBD. In addition, today the new ‘omics’ techniques have enabled us to draw up a functional and integrative map of the microbiota. The key concern in IBD is to develop biomarkers that allow us to assess the activity of the disease and predict the complications and progression, while also guiding the therapeutic care so as to develop personalized medicine. In this review, we present all of the latest discoveries on the microbiota provided by “omics” and we outline the benefits of these techniques in developing new diagnostic, prognostic and therapeutic tools.</jats:p>","is_dataset_classified":null,"base_score":3.784189633918261,"endowment":3.784189633918261,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34681921","pmcid":"PMC8537481","openalex_id":"https://openalex.org/W3206529882","authors":[],"funders":[],"total_grants":0,"fwci":3.1829,"citation_percentile":0.93493119,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":8},{"year":2023,"count":4},{"year":2024,"count":20},{"year":2025,"count":5},{"year":2026,"count":5}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/22/20/11255/pdf","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/22/20/11255/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms222011255","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34681921","host_type":"repository"},{"url":"https://hal.inrae.fr/hal-03402374","host_type":"repository"},{"url":"https://doaj.org/article/3f1611e925db4ee2881077a32730f9ea","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/ijms222011255","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8537481","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8537481","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8537481?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Gut microbiota and health","Inflammatory Bowel Disease","Helicobacter pylori-related gastroenterology studies","Bacteria","Disease Progression","Gastrointestinal Microbiome","Humans","Inflammatory Bowel Diseases","Metagenomics","Phylogeny","Precision Medicine"],"mesh_terms":["Gastrointestinal Microbiome","Bacteria","Humans","Phylogeny","Inflammatory Bowel Diseases","Disease Progression","Metagenomics","Precision Medicine"],"keywords":["Dysbiosis","Metagenomics","Omics","Gut flora","Inflammatory bowel disease","Ulcerative colitis","Inflammatory Bowel Diseases","Disease","Microbiome","Personalized medicine","Medicine","Crohn's disease","Bioinformatics","Computational biology","Biology","Immunology","Internal medicine","Microbiota","Crohn’s Disease"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T18:49:21.051916Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}