{"doi":"10.3390/ijms221910880","title":"Utilization of Pharmacological Ascorbate to Enhance Hydrogen Peroxide-Mediated Radiosensitivity in Cancer Therapy","abstract":"Interest in the use of pharmacological ascorbate as a treatment for cancer has increased considerably since it was introduced by Cameron and Pauling in the 1970s. Recently, pharmacological ascorbate has been used in preclinical and early-phase clinical trials as a selective radiation sensitizer in cancer. The results of these studies are promising. This review summarizes data on pharmacological ascorbate (1) as a safe and efficacious adjuvant to cancer therapy; (2) as a selective radiosensitizer of cancer via a mechanism involving hydrogen peroxide; and (3) as a radioprotector in normal tissues. Additionally, we present new data demonstrating the ability of pharmacological ascorbate to enhance radiation-induced DNA damage in glioblastoma cells, facilitating cancer cell death. We propose that pharmacological ascorbate may be a general radiosensitizer in cancer therapy and simultaneously a radioprotector of normal tissue.","journal":"International Journal of Molecular Sciences","year":2021,"id":186534,"datarank":0.4636563680037475,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.0,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9438,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":393432,"name":"Michael S. Petronek","orcid":"0000-0001-7581-1172","position":1,"is_corresponding":false},{"id":307489,"name":"Jeffrey M. Stolwijk","orcid":"0000-0001-6281-0103","position":2,"is_corresponding":false},{"id":297594,"name":"Kranti A. Mapuskar","orcid":"0000-0002-7311-7184","position":3,"is_corresponding":false},{"id":410378,"name":"Amanda L. Kalen","orcid":null,"position":4,"is_corresponding":false},{"id":297603,"name":"Garry R. Buettner","orcid":"0000-0002-5594-1903","position":5,"is_corresponding":false},{"id":401827,"name":"Joseph J. Cullen","orcid":"0000-0002-2222-1328","position":6,"is_corresponding":false},{"id":297605,"name":"Douglas R. Spitz","orcid":"0000-0002-1254-8765","position":7,"is_corresponding":false},{"id":14569,"name":"John M. Buatti","orcid":"0000-0001-8499-3721","position":8,"is_corresponding":false},{"id":393437,"name":"Bryan G. Allen","orcid":"0000-0002-4893-7105","position":9,"is_corresponding":false},{"id":744709,"name":"Zain Mehdi","orcid":"0000-0001-8251-4205","position":0,"is_corresponding":true}],"reference_count":102,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:48:46.850806Z","pmid":"34639220","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}