{"doi":"10.3390/ijms22116099","title":"Molecular Characterization of a Rare Case of Bilateral Vitreoretinal T Cell Lymphoma through Vitreous Liquid Biopsy","abstract":"Vitreoretinal lymphoma (VRL) is an uncommon eye malignancy, and VRLs of T cell origin are rare. They are difficult to treat, and their molecular underpinnings, including actionable genomic alterations, remain to be elucidated. At present, vitreous fluid liquid biopsies represent a valuable VRL sample for molecular analysis to study VRLs. In this study, we report the molecular diagnostic workup of a rare case of bilateral T cell VRL and characterize its genomic landscape, including identification of potentially targetable alterations. Using next-generation sequencing of vitreous-derived DNA with a pan-cancer 126-gene panel, we found a copy number gain of BRAF and copy number loss of tumor suppressor DNMT3A. To the best of our knowledge, this represents the first exploration of the T cell VRL cancer genome and supports vitreous liquid biopsy as a suitable approach for precision oncology treatments.","journal":"International Journal of Molecular Sciences","year":2021,"id":209194,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9449,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":414828,"name":"Marcus A. Toral","orcid":null,"position":1,"is_corresponding":false},{"id":367106,"name":"Daniel A. Balikov","orcid":"0000-0003-0392-5087","position":2,"is_corresponding":false},{"id":796792,"name":"Bryan L. Betz","orcid":null,"position":3,"is_corresponding":false},{"id":266949,"name":"Kevin Hu","orcid":"0000-0001-5513-7854","position":4,"is_corresponding":false},{"id":582189,"name":"Chia‐Jen Liu","orcid":"0000-0001-7945-9292","position":5,"is_corresponding":false},{"id":796381,"name":"Matthew V. Prifti","orcid":"0000-0001-8052-4063","position":6,"is_corresponding":false},{"id":51796,"name":"Arul M. Chinnaiyan","orcid":"0000-0001-9282-3415","position":7,"is_corresponding":false},{"id":64721,"name":"Scott A. Tomlins","orcid":"0000-0001-8661-9821","position":8,"is_corresponding":false},{"id":317223,"name":"Vinit B. Mahajan","orcid":"0000-0003-1886-1741","position":9,"is_corresponding":false},{"id":354064,"name":"Rajesh C. Rao","orcid":"0000-0002-5776-8366","position":10,"is_corresponding":false},{"id":720385,"name":"Andi K. Cani","orcid":"0000-0003-4691-656X","position":0,"is_corresponding":true}],"reference_count":18,"raw_metadata":null,"created_at":"2026-07-18T23:52:01.526969Z","pmid":"34198843","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}