{"doi":"10.3390/ijms22062785","title":"Crosstalk among Calcium ATPases: PMCA, SERCA and SPCA in Mental Diseases","abstract":"<jats:p>Calcium in mammalian neurons is essential for developmental processes, neurotransmitter release, apoptosis, and signal transduction. Incorrectly processed Ca2+ signal is well-known to trigger a cascade of events leading to altered response to variety of stimuli and persistent accumulation of pathological changes at the molecular level. To counterbalance potentially detrimental consequences of Ca2+, neurons are equipped with sophisticated mechanisms that function to keep its concentration in a tightly regulated range. Calcium pumps belonging to the P-type family of ATPases: plasma membrane Ca2+-ATPase (PMCA), sarco/endoplasmic Ca2+-ATPase (SERCA) and secretory pathway Ca2+-ATPase (SPCA) are considered efficient line of defense against abnormal Ca2+ rises. However, their role is not limited only to Ca2+ transport, as they present tissue-specific functionality and unique sensitive to the regulation by the main calcium signal decoding protein—calmodulin (CaM). Based on the available literature, in this review we analyze the contribution of these three types of Ca2+-ATPases to neuropathology, with a special emphasis on mental diseases.</jats:p>","journal":"International Journal of Molecular Sciences","year":2021,"id":29103,"datarank":0.9120891195318135,"base_score":3.367295829986474,"endowment":3.367295829986474,"self_citation_contribution":0.5050943744979712,"citation_network_contribution":0.4069947450338423,"self_endowment_contribution":0.5050943744979712,"citer_contribution":0.4069947450338423,"corpus_percentile":null,"corpus_rank":null,"citation_count":28,"citer_count":28,"citers_with_citation_signal":20,"citers_with_endowment":20,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":161265,"name":"Marta Sobolczyk","orcid":"0000-0002-3893-2335","position":1,"is_corresponding":false},{"id":161266,"name":"Joanna Mackiewicz","orcid":"0000-0001-5119-6101","position":2,"is_corresponding":false},{"id":161267,"name":"Malwina Lisek","orcid":null,"position":3,"is_corresponding":false},{"id":161268,"name":"Bozena Ferenc","orcid":null,"position":4,"is_corresponding":false},{"id":161270,"name":"Feng Guo","orcid":null,"position":5,"is_corresponding":false},{"id":161272,"name":"Ludmila Zylinska","orcid":"0000-0002-3876-8942","position":6,"is_corresponding":false},{"id":161264,"name":"Tomasz Boczek","orcid":"0000-0002-7654-9011","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.367295829986474,"endowment":3.367295829986474,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33801794","pmcid":"PMC8000800","openalex_id":"https://openalex.org/W3133696672","authors":[],"funders":[{"funder_name":"Narodowe Centrum Nauki","grant_id":"2019/33/B/NZ4/00587","title":null},{"funder_name":"Uniwersytet Medyczny w Lodzi","grant_id":"503/6-086-02/503-61-001","title":null}],"total_grants":2,"fwci":1.2213,"citation_percentile":0.78264475,"influential_citations":0,"citation_trend":[{"year":2022,"count":5},{"year":2023,"count":3},{"year":2024,"count":7},{"year":2025,"count":11},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/22/6/2785/pdf?version=1615356833","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/22/6/2785/pdf?version=1615356833","host_type":"GOLD"},{"url":"https://www.mdpi.com/1422-0067/22/6/2785/pdf?version=1615356833","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/22/6/2785/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms22062785","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33801794","host_type":"repository"},{"url":"https://doaj.org/article/8f1098794a7e4e20a570a201ce30ea54","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/ijms22062785","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8000800","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC8000800","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC8000800?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Ion channel regulation and function","Neuroscience and Neuropharmacology Research","Trace Elements in Health","Medicine","Biology","Animals","Calcium-Transporting ATPases","Humans","Mental Disorders","Models, Molecular","Nervous System Diseases","Plasma Membrane Calcium-Transporting ATPases","Protein Conformation","Sarcoplasmic Reticulum Calcium-Transporting ATPases"],"mesh_terms":["Calcium-Transporting ATPases","Animals","Mental Disorders","Humans","Models, Molecular","Nervous System Diseases","Protein Conformation","Sarcoplasmic Reticulum Calcium-Transporting ATPases","Plasma Membrane Calcium-Transporting ATPases"],"keywords":["SERCA","Calmodulin","Plasma membrane Ca2+ ATPase","Crosstalk","Cell biology","Biology","Signal transduction","ATPase","Calcium","Calcium signaling","Calcium ATPase","Endoplasmic reticulum","Biochemistry","Chemistry","Enzyme","Mental Diseases","Plasma Membrane Ca2+-atpase","Sarco/endoplasmic Ca2+-atpase","Secretory Pathway Ca2+-Atpase"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-08T22:39:44.466090Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}