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In this review, we summarize the complex interplay between hypoxia and the ER stress signaling pathways that are activated in the hypoxic microenvironment of the tumors.</jats:p>","journal":"International Journal of Molecular Sciences","year":2019,"id":685310,"datarank":0.7423139835567254,"base_score":4.948759890378168,"endowment":4.948759890378168,"self_citation_contribution":0.7423139835567254,"citation_network_contribution":0.0,"self_endowment_contribution":0.7423139835567254,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":140,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":12,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1790434,"name":"Elango Kannan","orcid":null,"position":1,"is_corresponding":false},{"id":1016013,"name":"Vinay Tergaonkar","orcid":"0000-0001-9009-0844","position":2,"is_corresponding":false},{"id":1790435,"name":"Richard D’Andrea","orcid":null,"position":3,"is_corresponding":false},{"id":859481,"name":"Nirmal Robinson","orcid":"0000-0002-7361-9491","position":4,"is_corresponding":false},{"id":1790433,"name":"Sandhya Chipurupalli","orcid":"0000-0002-2065-3880","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Hypoxia Induced ER Stress Response as an Adaptive Mechanism in Cancer","abstract":"<jats:p>It is evident that regions within tumors are deprived of oxygen, which makes the microenvironment hypoxic. Cancer cells experiencing hypoxia undergo metabolic alterations and cytoprotective adaptive mechanisms to survive such stringent conditions. While such mechanisms provide potential therapeutic targets, the mechanisms by which hypoxia regulates adaptive responses—such as ER stress response, unfolded protein response (UPR), anti-oxidative responses, and autophagy—remain elusive. In this review, we summarize the complex interplay between hypoxia and the ER stress signaling pathways that are activated in the hypoxic microenvironment of the tumors.</jats:p>","is_dataset_classified":null,"base_score":4.948759890378168,"endowment":4.948759890378168,"datacite_reuse_total":12,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"30754624","pmcid":"PMC6387291","openalex_id":"https://openalex.org/W2912315528","authors":[],"funders":[{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"CECAD D1","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"N31 SFB670","title":null},{"funder_name":"European Association for Cancer Research","grant_id":"Travel Fellowship","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"13123509/SFB 670","title":"Cell-autonomous Immunity"}],"total_grants":5,"fwci":7.2024,"citation_percentile":0.98333333,"influential_citations":0,"citation_trend":[{"year":2019,"count":6},{"year":2020,"count":14},{"year":2021,"count":31},{"year":2022,"count":20},{"year":2023,"count":18},{"year":2024,"count":21},{"year":2025,"count":20},{"year":2026,"count":10}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/20/3/749/pdf?version=1549871084","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/20/3/749/pdf?version=1549871084","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/20/3/749/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms20030749","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/30754624","host_type":"repository"},{"url":"http://europepmc.org/pmc/articles/PMC6387291","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6387291","host_type":"repository"},{"url":"https://find.library.unisa.edu.au/discovery/fulldisplay/alma9916263206101831/61USOUTHAUS_INST:ROR","host_type":"repository"},{"url":"https://doaj.org/article/7e218e45f98e429391d30f6fd69dd163","host_type":"repository"},{"url":"http://dx.doi.org/10.3390/ijms20030749","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6387291","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6387291?pdf=render","host_type":"Europe_PMC"},{"url":"https://dx.doi.org/10.3390/ijms20030749","host_type":""}],"fields_of_study":["Endoplasmic Reticulum Stress and Disease","Cancer, Hypoxia, and Metabolism","Mitochondrial Function and Pathology","0301 basic medicine","03 medical and health sciences"],"mesh_terms":["Adaptation, Biological","Animals","Hypoxia","Autophagy","Endoplasmic Reticulum","Humans","Neoplasms","Disease Progression","Hypoxia-Inducible Factor 1","Unfolded Protein Response","Tumor Microenvironment","Endoplasmic Reticulum Stress"],"keywords":["Hypoxia (environmental)","Adaptive response","Mechanism (biology)","Fight-or-flight response","Chemistry","Cancer research","Medicine","Biology","Oxygen","Biochemistry","Genetics","Physics","Gene","Hypoxia","Cancer","Endoplasmic reticulum","HIF-1","Upr","Stress-response","Adaptation, Biological","Review","Endoplasmic Reticulum Stress","Neoplasms","Autophagy","Disease Progression","Tumor Microenvironment","Unfolded Protein Response","Animals","Humans","Hypoxia-Inducible Factor 1"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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