{"doi":"10.3390/ijms18081601","title":"Updated Insight into the Physiological and Pathological Roles of the Retromer Complex","abstract":"<jats:p>Retromer complexes mediate protein trafficking from the endosomes to the trans-Golgi network (TGN) or through direct recycling to the plasma membrane. In yeast, they consist of a conserved trimer of the cargo selective complex (CSC), Vps26–Vps35–Vps29 and a dimer of sorting nexins (SNXs), Vps5–Vps17. In mammals, the CSC interacts with different kinds of SNX proteins in addition to the mammalian homologues of Vps5 and Vps17, which further diversifies retromer functions. The retromer complex plays important roles in many cellular processes including restriction of invading pathogens. In this review, we summarize some recent developments in our understanding of the physiological and pathological functions of the retromer complex.</jats:p>","journal":"International Journal of Molecular Sciences","year":2017,"id":593055,"datarank":0.9366795436965732,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.4215814630238013,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.4215814630238013,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":18,"citers_with_citation_signal":15,"citers_with_endowment":15,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1495633,"name":"Wenhui Zheng","orcid":"0009-0000-2767-3617","position":1,"is_corresponding":false},{"id":1517789,"name":"Stefan Olsson","orcid":null,"position":2,"is_corresponding":false},{"id":423632,"name":"Jie Zhou","orcid":"0000-0001-9309-8630","position":3,"is_corresponding":false},{"id":920943,"name":"Yakubu Saddeeq Abubakar","orcid":"0000-0002-5228-0548","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Updated Insight into the Physiological and Pathological Roles of the Retromer Complex","abstract":"<jats:p>Retromer complexes mediate protein trafficking from the endosomes to the trans-Golgi network (TGN) or through direct recycling to the plasma membrane. In yeast, they consist of a conserved trimer of the cargo selective complex (CSC), Vps26–Vps35–Vps29 and a dimer of sorting nexins (SNXs), Vps5–Vps17. In mammals, the CSC interacts with different kinds of SNX proteins in addition to the mammalian homologues of Vps5 and Vps17, which further diversifies retromer functions. The retromer complex plays important roles in many cellular processes including restriction of invading pathogens. In this review, we summarize some recent developments in our understanding of the physiological and pathological functions of the retromer complex.</jats:p>","is_dataset_classified":null,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28757549","pmcid":"PMC5577995","openalex_id":"https://openalex.org/W2737581548","authors":[],"funders":[],"total_grants":0,"fwci":2.2915,"citation_percentile":0.88564549,"influential_citations":0,"citation_trend":[{"year":2017,"count":1},{"year":2018,"count":5},{"year":2019,"count":1},{"year":2020,"count":7},{"year":2021,"count":3},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2024,"count":1},{"year":2025,"count":5},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/18/8/1601/pdf?version=1500973250","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/18/8/1601/pdf?version=1500973250","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/18/8/1601/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms18081601","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28757549","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5577995","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/ijms18081601","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5577995","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5577995?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Autophagy in Disease and Therapy","Mitochondrial Function and Pathology","Neutrophil, Myeloperoxidase and Oxidative Mechanisms"],"mesh_terms":["Animals","Autophagy","Humans","Endosomes","Protein Transport","trans-Golgi Network","Vesicular Transport Proteins","Multiprotein Complexes","Sorting Nexins"],"keywords":["Retromer","Pathological","Neuroscience","Computational biology","Endosome","Biology","Bioinformatics","Medicine","Cell biology","Pathology","Receptors","Disease","Vacuolar Protein Sorting"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T16:54:46.923633Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}