{"doi":"10.3390/ijms18061208","title":"RETRACTED: MicroRNA-223-3p Regulates Ovarian Cancer Cell Proliferation and Invasion by Targeting SOX11 Expression","abstract":"<jats:p>MicroRNAs (miRNAs) often display different expression in many cancers and other diseases in current research studies. miR-223 expression is upregulated in rheumatoid arthritis. Also, miR-223 expression has been demonstrated to be highly expressed in pancreatic cancer and gastric cancer in comparison with normal tissue. However, whether miR-223 displays different expression in ovarian cancer and what its underlying functions are in ovarian cancer have remained unclear. In this study, we demonstrated that miR-223-3p was upregulated in ovarian cancer tissue. Next, we explored the functional role of miR-223-3p in ovarian cancer using SKOV3 and OVCAR3 cell lines. Our results suggested that miR-223-3p mimic promoted ovarian cancer cell proliferation, migration, and invasion in vitro. However, miR-223-3p inhibitor displayed the opposite effects. In addition, we demonstrated that miR-223-3p mimic promoted tumor growth in vivo. Furthermore, we found SOX11 (sex determining region Y-box 11) was inversely expressed with miR-223-3p in ovarian cancer (OC) cell lines and tissue specimens. miR-223-3p mimic decreased SOX11 expression. Overexpressing SOX11 inhibited ovarian cancer cell proliferation and invasion, which indicated that miR-223-3p regulated OC cell proliferation and invasion through targeting SOX11 expression. In conclusion, the findings of the present study demonstrated that miR-223-3p could be a potential therapeutic for ovarian cancer.</jats:p>","journal":"International Journal of Molecular Sciences","year":2017,"id":609562,"datarank":0.6591673732008659,"base_score":4.394449154672439,"endowment":4.394449154672439,"self_citation_contribution":0.6591673732008659,"citation_network_contribution":0.0,"self_endowment_contribution":0.6591673732008659,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":80,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":10,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1377260,"name":"Jiao Liu","orcid":"0000-0002-8485-8332","position":1,"is_corresponding":false},{"id":1566830,"name":"Qianna Wang","orcid":null,"position":2,"is_corresponding":false},{"id":1566831,"name":"Xueqiong Huang","orcid":null,"position":3,"is_corresponding":false},{"id":1566832,"name":"Runwen Yang","orcid":null,"position":4,"is_corresponding":false},{"id":1566833,"name":"Yuzhou Pang","orcid":null,"position":5,"is_corresponding":false},{"id":1566834,"name":"Meichun Yang","orcid":null,"position":6,"is_corresponding":false},{"id":1317553,"name":"Gang Fang","orcid":"0000-0002-5409-3922","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"RETRACTED: MicroRNA-223-3p Regulates Ovarian Cancer Cell Proliferation and Invasion by Targeting SOX11 Expression","abstract":"<jats:p>MicroRNAs (miRNAs) often display different expression in many cancers and other diseases in current research studies. miR-223 expression is upregulated in rheumatoid arthritis. Also, miR-223 expression has been demonstrated to be highly expressed in pancreatic cancer and gastric cancer in comparison with normal tissue. However, whether miR-223 displays different expression in ovarian cancer and what its underlying functions are in ovarian cancer have remained unclear. In this study, we demonstrated that miR-223-3p was upregulated in ovarian cancer tissue. Next, we explored the functional role of miR-223-3p in ovarian cancer using SKOV3 and OVCAR3 cell lines. Our results suggested that miR-223-3p mimic promoted ovarian cancer cell proliferation, migration, and invasion in vitro. However, miR-223-3p inhibitor displayed the opposite effects. In addition, we demonstrated that miR-223-3p mimic promoted tumor growth in vivo. Furthermore, we found SOX11 (sex determining region Y-box 11) was inversely expressed with miR-223-3p in ovarian cancer (OC) cell lines and tissue specimens. miR-223-3p mimic decreased SOX11 expression. Overexpressing SOX11 inhibited ovarian cancer cell proliferation and invasion, which indicated that miR-223-3p regulated OC cell proliferation and invasion through targeting SOX11 expression. In conclusion, the findings of the present study demonstrated that miR-223-3p could be a potential therapeutic for ovarian cancer.</jats:p>","is_dataset_classified":null,"base_score":4.394449154672439,"endowment":4.394449154672439,"datacite_reuse_total":10,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28587313","pmcid":"PMC5486031","openalex_id":"https://openalex.org/W2621589379","authors":[],"funders":[],"total_grants":0,"fwci":2.2239,"citation_percentile":0.8804571,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":6},{"year":2019,"count":8},{"year":2020,"count":12},{"year":2021,"count":13},{"year":2022,"count":18},{"year":2023,"count":6},{"year":2024,"count":10},{"year":2025,"count":5}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/1422-0067/18/6/1208/pdf?version=1496752586","host_type":"journal"},{"url":"https://www.mdpi.com/1422-0067/18/6/1208/pdf?version=1496752586","host_type":"publisher"},{"url":"https://www.mdpi.com/1422-0067/18/6/1208/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/ijms18061208","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28587313","host_type":"repository"},{"url":"https://doaj.org/article/a377e571b4c441cc8ddaf7b4a2213f2b","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/ijms18061208","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5486031","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5486031","host_type":"Europe_PMC"}],"fields_of_study":["MicroRNA 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