{"doi":"10.3390/ijms161125934","title":"Proteomics Analysis of Cellular Proteins Co-Immunoprecipitated with Nucleoprotein of Influenza A Virus (H7N9)","abstract":"<jats:p>Avian influenza A viruses are serious veterinary pathogens that normally circulate among avian populations, causing substantial economic impacts. Some strains of avian influenza A viruses, such as H5N1, H9N2, and recently reported H7N9, have been occasionally found to adapt to humans from other species. In order to replicate efficiently in the new host, influenza viruses have to interact with a variety of host factors. In the present study, H7N9 nucleoprotein was transfected into human HEK293T cells, followed by immunoprecipitated and analyzed by proteomics approaches. A series of host proteins  co-immunoprecipitated were identified with high confidence, some of which were found to be acetylated at their lysine residues. Bioinformatics analysis revealed that spliceosome might be the most relevant pathway involved in host response to nucleoprotein expression, increasing our emerging knowledge of host proteins that might be involved in influenza virus replication activities.</jats:p>","journal":"International Journal of Molecular 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Virus Research Studies","RNA and protein synthesis mechanisms","interferon and immune responses","Medicine","Biology","Acetylation","Carrier Proteins","Computational Biology","Gene Expression","HEK293 Cells","Humans","Immunoprecipitation","Influenza A Virus, H7N9 Subtype","Influenza, Human","Lysine","Nucleocapsid Proteins","Protein Binding","Protein Interaction Mapping","Protein Interaction Maps","RNA-Binding Proteins","Tandem Mass Spectrometry","Viral Core Proteins"],"mesh_terms":["Acetylation","Carrier Proteins","Humans","Influenza, Human","Lysine","Protein Binding","Viral Core Proteins","Gene Expression","RNA-Binding Proteins","Computational Biology","Nucleocapsid Proteins","Protein Interaction Mapping","Immunoprecipitation","Tandem Mass Spectrometry","HEK293 Cells","Protein Interaction Maps","Influenza A Virus, H7N9 Subtype"],"keywords":["Nucleoprotein","Influenza A virus subtype H5N1","Influenza A virus","Biology","Virology","Virus","Immunoprecipitation","Proteomics","Host 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