{"doi":"10.3390/ijerph17186639","title":"Two-Year Scale-Up of Seasonal Malaria Chemoprevention Reduced Malaria Morbidity among Children in the Health District of Koutiala, Mali","abstract":"Background: Previous controlled studies demonstrated seasonal malaria chemoprevention (SMC) reduces malaria morbidity by >80% in children aged 3–59 months. Here, we assessed malaria morbidity after large-scale SMC implementation during a pilot campaign in the health district of Koutiala, Mali. Methods: Starting in August 2012, children received three rounds of SMC with sulfadoxine-pyrimethamine (SP) and amodiaquine (AQ). From July 2013 onward, children received four rounds of SMC. Prevalence of malaria infection, clinical malaria and anemia were assessed during two cross-sectional surveys conducted in August 2012 and June 2014. Investigations involved 20 randomly selected clusters in 2012 against 10 clusters in 2014. Results: Overall, 662 children were included in 2012, and 670 in 2014. Children in 2014 versus those surveyed in 2012 showed reduced proportions of malaria infection (12.4% in 2014 versus 28.7% in 2012 (p = 0.001)), clinical malaria (0.3% versus 4.2%, respectively (p < 0.001)), and anemia (50.1% versus 67.4%, respectively (p = 0.001)). A propensity score approach that accounts for environmental differences showed that SMC conveyed a significant protective effect against malaria infection (IR = 0.01, 95% CI (0.0001; 0.09), clinical malaria (OR = 0.25, 95% CI (0.06; 0.85)), and hemoglobin concentration (β = 1.3, 95% CI (0.69; 1.96)) in 2012 and 2014, respectively. Conclusion: SMC significantly reduced frequency of malaria infection, clinical malaria and anemia two years after SMC scale-up in Koutiala.","journal":"International Journal of Environmental Research and Public Health","year":2020,"id":105709,"datarank":0.47670807455219194,"base_score":3.1780538303479458,"endowment":3.1780538303479458,"self_citation_contribution":0.47670807455219194,"citation_network_contribution":0.0,"self_endowment_contribution":0.47670807455219194,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":23,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9535,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":403044,"name":"Jean Gaudart","orcid":"0000-0001-9006-5729","position":1,"is_corresponding":false},{"id":334202,"name":"Issaka Sagara","orcid":"0000-0002-8555-9983","position":2,"is_corresponding":false},{"id":511382,"name":"Modibo Diarra","orcid":"0000-0001-7866-9351","position":3,"is_corresponding":false},{"id":511750,"name":"Amadou Bamadio","orcid":null,"position":4,"is_corresponding":false},{"id":511383,"name":"Moussa Djimdé","orcid":"0000-0002-1820-2917","position":5,"is_corresponding":false},{"id":511751,"name":"Samba Coumaré","orcid":null,"position":6,"is_corresponding":false},{"id":511752,"name":"Boubou Sangare","orcid":null,"position":7,"is_corresponding":false},{"id":511753,"name":"Yeyia Dicko","orcid":null,"position":8,"is_corresponding":false},{"id":511754,"name":"Aly Tembély","orcid":null,"position":9,"is_corresponding":false},{"id":511755,"name":"Djibril Traoré","orcid":null,"position":10,"is_corresponding":false},{"id":334203,"name":"Alassane Dicko","orcid":"0000-0003-2153-8427","position":11,"is_corresponding":false},{"id":511756,"name":"Estrella Lasry","orcid":null,"position":12,"is_corresponding":false},{"id":431079,"name":"Ogobara K. Doumbo","orcid":null,"position":13,"is_corresponding":false},{"id":260121,"name":"Abdoulaye Djimdé","orcid":"0000-0003-0062-2283","position":14,"is_corresponding":false},{"id":260123,"name":"Hamma Maiga","orcid":"0000-0002-5849-0562","position":0,"is_corresponding":true}],"reference_count":36,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:12:21.275494Z","pmid":"32932990","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}