{"doi":"10.3390/ijerph17051747","title":"A Cohort Study of Exposure to Antihyperglycemic Therapy and Survival in Patients with Lung Cancer","abstract":"<jats:p>We evaluated the effect of antihyperglycemic therapy on the survival of patients with lung cancer (LC). The analysis included patients with LC and concomitant type 2 diabetes. 15,929 patients were classified into five groups: metformin users, insulin users, metformin and insulin users, sulphonylurea users and non-diabetic group. A multivariate analysis showed that exposure to either metformin or to insulin was associated with a lower risk of LC-specific mortality, and this approached statistical significance (HR 0.82, 95% CI 0.72–92 for metformin and HR 0.65, 95% CI 0.44–95 for insulin). When deaths from all causes were considered, only metformin exposure was associated with a significantly lower risk of death (HR 0.82, 95% CI 0.73–0.92). Users of sulphonylurea were at a higher risk of LC-specific and overall mortality (HRs 1.19, 95% CI 0.99–1.43 and 1.22, 95% CI 1.03–1.45). Our study shows a positive effect of metformin on the survival of patients with LC. Moreover, our results show that exposure to insulin was associated with a lower risk of LC-specific mortality, but not with deaths from all causes. The study results suggested that users of sulphonylurea may be at a higher risk of LC-specific and overall mortality.</jats:p>","journal":"International Journal of Environmental Research and Public Health","year":2020,"id":626075,"datarank":0.26876392038420827,"base_score":1.791759469228055,"endowment":1.791759469228055,"self_citation_contribution":0.26876392038420827,"citation_network_contribution":0.0,"self_endowment_contribution":0.26876392038420827,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1619418,"name":"Donata Linkevičiūtė-Ulinskienė","orcid":null,"position":1,"is_corresponding":false},{"id":1619420,"name":"Rolandas Zablockis","orcid":null,"position":2,"is_corresponding":false},{"id":1619422,"name":"Vygantas Gruslys","orcid":null,"position":3,"is_corresponding":false},{"id":1619424,"name":"Saulius Cicėnas","orcid":null,"position":4,"is_corresponding":false},{"id":1619425,"name":"Giedrė Smailytė","orcid":"0000-0001-8365-543X","position":5,"is_corresponding":false},{"id":1619417,"name":"Edvardas Danila","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"A Cohort Study of Exposure to Antihyperglycemic Therapy and Survival in Patients with Lung Cancer","abstract":"<jats:p>We evaluated the effect of antihyperglycemic therapy on the survival of patients with lung cancer (LC). The analysis included patients with LC and concomitant type 2 diabetes. 15,929 patients were classified into five groups: metformin users, insulin users, metformin and insulin users, sulphonylurea users and non-diabetic group. A multivariate analysis showed that exposure to either metformin or to insulin was associated with a lower risk of LC-specific mortality, and this approached statistical significance (HR 0.82, 95% CI 0.72–92 for metformin and HR 0.65, 95% CI 0.44–95 for insulin). When deaths from all causes were considered, only metformin exposure was associated with a significantly lower risk of death (HR 0.82, 95% CI 0.73–0.92). Users of sulphonylurea were at a higher risk of LC-specific and overall mortality (HRs 1.19, 95% CI 0.99–1.43 and 1.22, 95% CI 1.03–1.45). Our study shows a positive effect of metformin on the survival of patients with LC. Moreover, our results show that exposure to insulin was associated with a lower risk of LC-specific mortality, but not with deaths from all causes. The study results suggested that users of sulphonylurea may be at a higher risk of LC-specific and overall mortality.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"32156062","pmcid":"PMC7084663","openalex_id":null,"authors":[],"funders":[{"funder_name":"National Health and Medical Research Council (NHMRC)","grant_id":"158200","title":"Ongoing uncoupled research fellowship"}],"total_grants":1,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"CC BY","oa_locations":[{"url":"https://www.mdpi.com/1660-4601/17/5/1747/pdf","host_type":"publisher"},{"url":"https://www.mdpi.com/1660-4601/17/5/1747/pdf?version=1583581675","host_type":"Unpaywall"},{"url":"https://europepmc.org/articles/PMC7084663","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7084663?pdf=render","host_type":"Europe_PMC"},{"url":"https://doi.org/10.3390/ijerph17051747","host_type":""},{"url":"https://pubmed.ncbi.nlm.nih.gov/32156062","host_type":""},{"url":"http://dx.doi.org/10.3390/ijerph17051747","host_type":""},{"url":"https://dx.doi.org/10.3390/ijerph17051747","host_type":""},{"url":"https://repository.vu.lt/VU:ELABAPDB53276993&prefLang=en_US","host_type":""}],"fields_of_study":["03 medical and health sciences","0302 clinical medicine"],"mesh_terms":["Humans","Lung Neoplasms","Diabetes Mellitus, Type 2","Metformin","Hypoglycemic Agents","Cohort Studies","Female","Male"],"keywords":["Insulin","Lung cancer","Diabetes","Metformin","Male","Lung Neoplasms","Article","Cohort Studies","Diabetes Mellitus, Type 2","Humans","Hypoglycemic Agents","Female"],"sdg_mappings":[{"sdg_number":3,"sdg_label":"3. 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