{"doi":"10.3390/genes6020299","title":"Chromatin Remodelers: From Function to Dysfunction","abstract":"<jats:p>Chromatin remodelers are key players in the regulation of chromatin accessibility and nucleosome positioning on the eukaryotic DNA, thereby essential for all DNA dependent biological processes. Thus, it is not surprising that upon of deregulation of those molecular machines healthy cells can turn into cancerous cells. Even though the remodeling enzymes are very abundant and a multitude of different enzymes and chromatin remodeling complexes exist in the cell, the particular remodeling complex with its specific nucleosome positioning features must be at the right place at the right time in order to ensure the proper regulation of the DNA dependent processes. To achieve this, chromatin remodeling complexes harbor protein domains that specifically read chromatin targeting signals, such as histone modifications, DNA sequence/structure, non-coding RNAs, histone variants or DNA bound interacting proteins. Recent studies reveal the interaction between non-coding RNAs and chromatin remodeling complexes showing importance of RNA in remodeling enzyme targeting, scaffolding and regulation. In this review, we summarize current understanding of chromatin remodeling enzyme targeting to chromatin and their role in cancer development.</jats:p>","journal":"Genes","year":2015,"id":20756,"datarank":3.8260306403369353,"base_score":5.153291594497779,"endowment":5.153291594497779,"self_citation_contribution":0.772993739174667,"citation_network_contribution":3.0530369011622684,"self_endowment_contribution":0.772993739174667,"citer_contribution":3.0530369011622684,"corpus_percentile":null,"corpus_rank":null,"citation_count":172,"citer_count":169,"citers_with_citation_signal":127,"citers_with_endowment":127,"datacite_reuse_total":1,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":136131,"name":"Laura Manelyte","orcid":null,"position":1,"is_corresponding":false},{"id":111750,"name":"Gernot Längst","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.153291594497779,"endowment":5.153291594497779,"datacite_reuse_total":1,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"26075616","pmcid":"PMC4488666","openalex_id":"https://openalex.org/W1511164184","authors":[],"funders":[{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"SFB960","title":null},{"funder_name":"Universität Regensburg","grant_id":"Frauenförderung","title":null},{"funder_name":"Deutsche Forschungsgemeinschaft","grant_id":"unidentified","title":"unidentified"}],"total_grants":3,"fwci":8.131,"citation_percentile":0.98147894,"influential_citations":10,"citation_trend":[{"year":2015,"count":4},{"year":2016,"count":17},{"year":2017,"count":12},{"year":2018,"count":21},{"year":2019,"count":23},{"year":2020,"count":17},{"year":2021,"count":18},{"year":2022,"count":12},{"year":2023,"count":27},{"year":2024,"count":9},{"year":2025,"count":8},{"year":2026,"count":4}],"oa_status":"gold","license":"other-oa","oa_locations":[{"url":"https://www.mdpi.com/2073-4425/6/2/299/pdf?version=1434109276","host_type":"journal"},{"url":"https://www.mdpi.com/2073-4425/6/2/299/pdf?version=1434109276","host_type":"GOLD"},{"url":"https://www.mdpi.com/2073-4425/6/2/299/pdf?version=1434109276","host_type":"publisher"},{"url":"https://www.mdpi.com/2073-4425/6/2/299/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/genes6020299","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/26075616","host_type":"repository"},{"url":"https://doaj.org/article/185e93acd0164184a8e758d36fb1f03f","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4488666","host_type":"repository"},{"url":"http://dx.doi.org/10.3390/genes6020299","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC4488666","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC4488666?pdf=render","host_type":"Europe_PMC"},{"url":"https://dx.doi.org/10.5283/epub.31952","host_type":""},{"url":"https://dx.doi.org/10.3390/genes6020299","host_type":""},{"url":"https://epub.uni-regensburg.de/31952/","host_type":""}],"fields_of_study":["Chromatin Remodeling and Cancer","Genomics and Chromatin Dynamics","Protein Degradation and Inhibitors","Biology","Medicine","0301 basic medicine","03 medical and health sciences"],"mesh_terms":[],"keywords":["Chromatin remodeling","Chromatin","Biology","Nucleosome","Histone-modifying enzymes","ChIA-PET","Histone","Cell biology","Scaffold/matrix attachment region","Bivalent chromatin","Histone code","Computational biology","DNA","Genetics","Cancer","non-coding RNA","Chromatin Remodeler","Search Mechanism","Arrest Model","570 Biowissenschaften, Biologie","ddc:570","Review","chromatin remodeler; cancer; search mechanism; arrest model; non-coding RNA"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.5283/epub.31952","title":"Chromatin remodelers: from function to dysfunction","publisher":"Universität Regensburg","resource_type":"Text"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-06T10:33:06.393055Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}