{"doi":"10.3390/genes14020517","title":"An Introduction and Overview of RON Receptor Tyrosine Kinase Signaling","abstract":"RON is a receptor tyrosine kinase (RTK) of the MET receptor family that is canonically involved in mediating growth and inflammatory signaling. RON is expressed at low levels in a variety of tissues, but its overexpression and activation have been associated with malignancies in multiple tissue types and worse patient outcomes. RON and its ligand HGFL demonstrate cross-talk with other growth receptors and, consequentially, positions RON at the intersection of numerous tumorigenic signaling programs. For this reason, RON is an attractive therapeutic target in cancer research. A better understanding of homeostatic and oncogenic RON activity serves to enhance clinical insights in treating RON-expressing cancers.","journal":"Genes","year":2023,"id":340717,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9532,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1075762,"name":"Levi H. Fox","orcid":"0000-0002-2996-1150","position":1,"is_corresponding":false},{"id":947120,"name":"James C. Davis","orcid":"0000-0002-8645-9247","position":2,"is_corresponding":false},{"id":947119,"name":"Angelle D. Jones","orcid":"0000-0003-3828-1808","position":3,"is_corresponding":false},{"id":1075763,"name":"Zhixin Lu","orcid":"0000-0002-7900-0200","position":4,"is_corresponding":false},{"id":413462,"name":"Susan E. Waltz","orcid":"0000-0003-3572-4642","position":5,"is_corresponding":false},{"id":707901,"name":"Brian G. Hunt","orcid":"0000-0003-4155-730X","position":0,"is_corresponding":true}],"reference_count":123,"raw_metadata":null,"created_at":"2026-07-19T01:10:58.548803Z","pmid":"36833444","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}