{"doi":"10.3390/genes12081166","title":"Roles for α-Synuclein in Gene Expression","abstract":"α-Synuclein (α-Syn) is a small cytosolic protein associated with a range of cellular compartments, including synaptic vesicles, the nucleus, mitochondria, endoplasmic reticulum, Golgi apparatus, and lysosomes. In addition to its physiological role in regulating presynaptic function, the protein plays a central role in both sporadic and familial Parkinson's disease (PD) via a gain-of-function mechanism. Because of this, several recent strategies propose to decrease α-Syn levels in PD patients. While these therapies may offer breakthroughs in PD management, the normal functions of α-Syn and potential side effects of its depletion require careful evaluation. Here, we review recent evidence on physiological and pathological roles of α-Syn in regulating activity-dependent signal transduction and gene expression pathways that play fundamental role in synaptic plasticity.","journal":"Genes","year":2021,"id":168027,"datarank":0.519860385419959,"base_score":3.4657359027997265,"endowment":3.4657359027997265,"self_citation_contribution":0.519860385419959,"citation_network_contribution":0.0,"self_endowment_contribution":0.519860385419959,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":31,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9533,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":697289,"name":"Zina Lanseur","orcid":null,"position":1,"is_corresponding":false},{"id":618675,"name":"Se Joon Choi","orcid":"0000-0002-5486-7326","position":2,"is_corresponding":false},{"id":230247,"name":"David Sulzer","orcid":"0000-0001-7632-0439","position":3,"is_corresponding":false},{"id":570355,"name":"Eugene V. Mosharov","orcid":"0000-0002-0229-7114","position":4,"is_corresponding":false},{"id":570353,"name":"Mahalakshmi Somayaji","orcid":"0000-0002-6209-9400","position":0,"is_corresponding":true}],"reference_count":158,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-18T23:46:02.603031Z","pmid":"34440340","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}