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Anionic microgels require the presence of multivalent cations (Ca2+) to promote the complexation, overcoming the electrostatic repulsion with negatively charged DNA. Then again, Langmuir monolayers evidence their complexation at the surface. However, the presence of Ca2+ seems to induce profound changes in the interaction and surface conformation of anionic microgels. These alterations are further explored by measuring adsorbed films with the pendant drop technique. Conformational changes induced by Ca2+ on the structure of the microgel can ultimately affect the complexation with DNA and should be considered in the design. The combination of microstructural and surface properties for microgels offers a new perspective into complexation of DNA with soft particles with biomedical applications.</jats:p>","journal":"Gels","year":2022,"id":660632,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1445821,"name":"Yan Yang","orcid":"0000-0003-1135-8406","position":1,"is_corresponding":false},{"id":1724579,"name":"Maykel Jiménez-Guerra","orcid":"0000-0002-1778-8805","position":2,"is_corresponding":false},{"id":1724580,"name":"Teresa del Castillo-Santaella","orcid":"0000-0002-8387-5560","position":3,"is_corresponding":false},{"id":1724581,"name":"José Ramos","orcid":null,"position":4,"is_corresponding":false},{"id":1724582,"name":"Alberto Martín-Molina","orcid":"0000-0001-8023-8665","position":5,"is_corresponding":false},{"id":1724576,"name":"Julia Maldonado-Valderrama","orcid":"0000-0001-6372-723X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Complexation of DNA with Thermoresponsive Charged Microgels: Role of Swelling State and Electrostatics","abstract":"<jats:p>Micro- and nanogels are being increasingly used to encapsulate bioactive compounds. 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