{"doi":"10.3390/ecsa-10-16065","title":"Bioengineered Monoclonal Antibody Chitosan–Iron Oxide Bio-Composite for Electrochemical Sensing of Mycobacterium tuberculosis Lipoprotein","abstract":"In this study, an electrochemical immunosensor for the detection of the 19 kDa Mycobacterium tuberculosis lipoprotein LpqH was developed using a monoclonal antibody immobilized on a chitosan-coated iron oxide bio-composite. The bio-composite is composed of magnetic iron oxide at its core and a non-magnetic thin film on the surface formed by chitosan, providing the chemistry for monoclonal antibody immobilization. Cyclic voltammetry was used to characterize and test the immunosensor assembly. Electrochemical measurements showed a strong relationship between the LpqH concentration in phosphate-buffered saline solution and the measured anodic peak current. The electrochemical immunosensor showed a limit of detection equal to 40 μg/mL (2 μM) LpqH.","journal":"DOAJ (DOAJ: Directory of Open Access Journals)","year":2023,"id":415313,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9591,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1197350,"name":"Glenson R. Panghulan","orcid":"0000-0001-5210-5654","position":1,"is_corresponding":false},{"id":1197606,"name":"Clydee Ann T. Hernandez","orcid":null,"position":2,"is_corresponding":false},{"id":1197607,"name":"Jeffrey P. Tamayo","orcid":null,"position":3,"is_corresponding":false},{"id":1197349,"name":"Resmond L. Reaño","orcid":"0000-0002-4763-468X","position":0,"is_corresponding":true}],"reference_count":11,"raw_metadata":null,"created_at":"2026-07-19T01:22:12.933438Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}