{"doi":"10.3390/diagnostics12051164","title":"Rapid Quantum Magnetic IL-6 Point-of-Care Assay in Patients Hospitalized with COVID-19","abstract":"Interleukin-6 (IL-6) has been linked to several life-threatening disease processes. Developing a point-of-care testing platform for the immediate and accurate detection of IL-6 concentrations could present a valuable tool for improving clinical management in patients with IL-6-mediated diseases. Drawing on an available biobank of samples from 35 patients hospitalized with COVID-19, a novel quantum-magnetic sensing platform is used to determine plasma IL-6 concentrations. A strong correlation was observed between IL-6 levels measured by QDTI10x and the Luminex assay (r = 0.70, p-value < 0.001) and between QDTI80x and Luminex (r = 0.82, p-value < 0.001). To validate the non-inferiority of QDTI to Luminex in terms of the accuracy of IL-6 measurement, two clinical parameters—the need for intensive care unit admission and the need for mechanical intubation—were chosen. IL-6 concentrations measured by the two assays were compared with respect to these clinical outcomes. Results demonstrated a comparative predictive performance between the two assays with a significant correlation coefficient. Conclusion: In short, the QDTI assay holds promise for implementation as a potential tool for rapid clinical decision in patients with IL-6-mediated diseases. It could also reduce healthcare costs and enable the development of future various biomolecule point-of-care tests for different clinical scenarios.","journal":"Diagnostics","year":2022,"id":265807,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":924955,"name":"Dakota Archambault","orcid":"0000-0002-2088-9324","position":1,"is_corresponding":false},{"id":925398,"name":"Jeffrey Randall","orcid":null,"position":2,"is_corresponding":false},{"id":925399,"name":"Adam Shepro","orcid":null,"position":3,"is_corresponding":false},{"id":925400,"name":"Lauren E. Styskal","orcid":null,"position":4,"is_corresponding":false},{"id":925401,"name":"David R. Glenn","orcid":null,"position":5,"is_corresponding":false},{"id":925402,"name":"Colin B. Connolly","orcid":null,"position":6,"is_corresponding":false},{"id":627236,"name":"Katelin Katsis","orcid":null,"position":7,"is_corresponding":false},{"id":626228,"name":"Kathleen Gallagher","orcid":"0000-0002-6952-7885","position":8,"is_corresponding":false},{"id":249351,"name":"Musie Ghebremichael","orcid":"0000-0002-8572-1944","position":9,"is_corresponding":false},{"id":89098,"name":"Michael K. Mansour","orcid":"0000-0001-8892-8695","position":10,"is_corresponding":false},{"id":924954,"name":"Johnny Atallah","orcid":"0000-0003-0681-9087","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T00:26:49.862989Z","pmid":"35626318","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}