{"doi":"10.3390/curroncol32050271","title":"Drug Sensitivity Testing in Osteosarcoma: A Case Report","abstract":"Precision medicine approaches using ex-vivo drug sensitivity testing (DST) have received attention in the cancer research community as a means to improve treatment stratification in populations where multiple treatment attempts are not feasible, or no standard-of-care treatment exists, such as ultra-rare cancers with a significant clinical need for effective treatment options, like osteosarcoma. DST has the potential to supplement existing patient stratification approaches by providing tumor-specific response data to aid in treatment selection at the time of treatment decision. We present the case of a pediatric osteosarcoma patient who was evaluated using DST at the time of standard-of-care treatment to evaluate treatment sensitivity. The DST screen indicated significant treatment sensitivity to anthracyclines and methotrexate, consistent with the first-line standard-of-care therapy (MAP). Clinical follow-up showed treatment sensitivity to standard-of-care MAP treatment and pathology results of 90% necrosis. The present case shows that DST screening is feasible from a technical standpoint, can be performed in a clinically relevant time frame that does not delay treatment start, and provides personalized drug sensitivity information on clinically available agents, and the DST results align with the clinical treatment response.","journal":"Current Oncology","year":2025,"id":544090,"datarank":0.10397207708399181,"base_score":0.6931471805599453,"endowment":0.6931471805599453,"self_citation_contribution":0.10397207708399181,"citation_network_contribution":0.0,"self_endowment_contribution":0.10397207708399181,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9482,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":867946,"name":"Giselle Dutcher","orcid":null,"position":1,"is_corresponding":false},{"id":320998,"name":"Hassan Al‐Ali","orcid":"0000-0002-8899-3443","position":2,"is_corresponding":false},{"id":536527,"name":"Warren Alperstein","orcid":"0000-0002-1802-5025","position":3,"is_corresponding":false},{"id":312106,"name":"Donald W. Coulter","orcid":"0000-0002-7829-0971","position":4,"is_corresponding":false},{"id":329716,"name":"Matteo Trucco","orcid":"0000-0002-1819-024X","position":5,"is_corresponding":false},{"id":260070,"name":"Jonathan C. Trent","orcid":"0000-0001-6169-5238","position":6,"is_corresponding":false},{"id":279165,"name":"Claes Wahlestedt","orcid":"0000-0003-4471-5916","position":7,"is_corresponding":false},{"id":353035,"name":"Ines Lohse","orcid":"0000-0002-9979-9400","position":0,"is_corresponding":true}],"reference_count":28,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:53:08.338070Z","pmid":"40422530","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}