{"doi":"10.3390/children10121871","title":"Practice Variation among Pediatric Endocrinologists in the Dosing of Glucocorticoids in Young Children with Congenital Adrenal Hyperplasia","abstract":"A Pediatric Endocrine Society (PES) Drugs and Therapeutics Committee workgroup sought to determine the prescribing practices of pediatric endocrinologists when treating children <10 years of age with congenital adrenal hyperplasia (CAH). Our workgroup administered a 32-question online survey to PES members. There were 187 respondents (88.9% attending physicians), mostly from university-affiliated clinics (~80%). Ninety-eight percent of respondents prescribed the short-acting glucocorticoid hydrocortisone to treat young children, as per the Endocrine Society CAH Guidelines, although respondents also prescribed long-acting glucocorticoids such as prednisolone suspension (12%), prednisone tablets (9%), and prednisone suspension (6%). Ninety-seven percent of respondents indicated that they were likely/very likely to prescribe hydrocortisone in a thrice-daily regimen, as per CAH Guidelines, although 19% were also likely to follow a twice-daily regimen. To achieve smaller doses, using a pill-cutter was the most frequent method recommended by providers to manipulate tablets (87.2%), followed by dissolving tablets in water (25.7%) to create a daily batch (43.7%) and/or dissolving a tablet for each dose (64.6%). Thirty-one percent of providers use pharmacy-compounded hydrocortisone suspension to achieve doses of <2.5 mg. Our survey shows that practices among providers in the dosing of young children with CAH vary greatly and sometimes fall outside of the CAH Guidelines-specifically when attempting to deliver lower, age-appropriate hydrocortisone doses.","journal":"Children","year":2023,"id":378097,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9345,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1142056,"name":"Amit Lahoti","orcid":"0000-0003-0039-8701","position":1,"is_corresponding":false},{"id":1142482,"name":"Leslie Long Simpson","orcid":null,"position":2,"is_corresponding":false},{"id":718033,"name":"Elise F. Palzer","orcid":"0000-0003-3732-0844","position":3,"is_corresponding":false},{"id":536229,"name":"Paul Thornton","orcid":"0000-0002-9706-5665","position":4,"is_corresponding":false},{"id":1142057,"name":"Ryan Heksch","orcid":"0000-0002-8845-5725","position":5,"is_corresponding":false},{"id":739739,"name":"Manmohan K. Kamboj","orcid":"0009-0002-1635-6725","position":6,"is_corresponding":false},{"id":270863,"name":"Takara L. Stanley","orcid":"0000-0002-2336-2958","position":7,"is_corresponding":false},{"id":298501,"name":"Molly O. Regelmann","orcid":"0000-0001-8946-5717","position":8,"is_corresponding":false},{"id":584516,"name":"Anshu Gupta","orcid":"0000-0003-4849-919X","position":9,"is_corresponding":false},{"id":740423,"name":"Vandana Raman","orcid":null,"position":10,"is_corresponding":false},{"id":743612,"name":"Shilpa Mehta","orcid":"0000-0002-4494-5861","position":11,"is_corresponding":false},{"id":371304,"name":"Mitchell E. Geffner","orcid":"0000-0002-0384-3287","position":12,"is_corresponding":false},{"id":436044,"name":"Kyriakie Sarafoglou","orcid":"0000-0002-5741-3629","position":13,"is_corresponding":false},{"id":787556,"name":"Heba Al-Rayess","orcid":null,"position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T01:16:44.708019Z","pmid":"38136073","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}