{"doi":"10.3390/cells9102277","title":"The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders","abstract":"<jats:p>Fractalkine (FKN, CX3CL1) is a transmembrane chemokine expressed by neurons in the central nervous system (CNS). CX3CL1 signals through its unique receptor, CX3CR1, that is expressed in microglia. Within the CNS, fractalkine acts as a regulator of microglia activation in response to brain injury or inflammation. During the last decade, there has been a growing interest in the roles that the CX3CL1/CX3CR1 signaling pathway plays in the neuropathology of a diverse array of brain disorders. However, the reported results have proven controversial, indicating that a disruption of the CX3CL1 axis induces a disease-specific microglial response that may have either beneficial or detrimental effects. Therefore, it has become clear that the understanding of neuron-to-glia signals mediated by CX3CL1/CX3CR1 at different stages of diseases could provide new insight into potential therapeutic targets. Hence, the aim of this review is to provide a summary of the literature on the emerging role of CX3CL1 in animal models of some brain disorders.</jats:p>","journal":"Cells","year":2020,"id":602320,"datarank":0.839206706940276,"base_score":5.594711379601839,"endowment":5.594711379601839,"self_citation_contribution":0.839206706940276,"citation_network_contribution":0.0,"self_endowment_contribution":0.839206706940276,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":268,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1544673,"name":"Malgorzata Ziemka-Nalecz","orcid":null,"position":1,"is_corresponding":false},{"id":1544674,"name":"Joanna Sypecka","orcid":null,"position":2,"is_corresponding":false},{"id":1544675,"name":"Teresa Zalewska","orcid":"0000-0002-4301-9495","position":3,"is_corresponding":false},{"id":1544672,"name":"Paulina Pawelec","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The Impact of the CX3CL1/CX3CR1 Axis in Neurological Disorders","abstract":"<jats:p>Fractalkine (FKN, CX3CL1) is a transmembrane chemokine expressed by neurons in the central nervous system (CNS). CX3CL1 signals through its unique receptor, CX3CR1, that is expressed in microglia. Within the CNS, fractalkine acts as a regulator of microglia activation in response to brain injury or inflammation. During the last decade, there has been a growing interest in the roles that the CX3CL1/CX3CR1 signaling pathway plays in the neuropathology of a diverse array of brain disorders. However, the reported results have proven controversial, indicating that a disruption of the CX3CL1 axis induces a disease-specific microglial response that may have either beneficial or detrimental effects. Therefore, it has become clear that the understanding of neuron-to-glia signals mediated by CX3CL1/CX3CR1 at different stages of diseases could provide new insight into potential therapeutic targets. Hence, the aim of this review is to provide a summary of the literature on the emerging role of CX3CL1 in animal models of some brain disorders.</jats:p>","is_dataset_classified":null,"base_score":5.594711379601839,"endowment":5.594711379601839,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"33065974","pmcid":"PMC7600611","openalex_id":"https://openalex.org/W3091912339","authors":[],"funders":[{"funder_name":"Narodowe Centrum Nauki","grant_id":"2017/27/B/NZ3/00582","title":null}],"total_grants":1,"fwci":8.8761,"citation_percentile":0.98353488,"influential_citations":0,"citation_trend":[{"year":2021,"count":19},{"year":2022,"count":41},{"year":2023,"count":45},{"year":2024,"count":63},{"year":2025,"count":67},{"year":2026,"count":33}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://www.mdpi.com/2073-4409/9/10/2277/pdf?version=1602567904","host_type":"journal"},{"url":"https://www.mdpi.com/2073-4409/9/10/2277/pdf?version=1602567904","host_type":"publisher"},{"url":"https://www.mdpi.com/2073-4409/9/10/2277/pdf","host_type":"publisher"},{"url":"https://doi.org/10.3390/cells9102277","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/33065974","host_type":"repository"},{"url":"https://doaj.org/article/10dc1eba562840ab870f447333cfc11f","host_type":"repository"},{"url":"https://dx.doi.org/10.3390/cells9102277","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/7600611","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC7600611","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC7600611?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Neuroinflammation and Neurodegeneration Mechanisms","Chemokine receptors and signaling","Immune cells in cancer","Animals","CX3C Chemokine Receptor 1","Chemokine CX3CL1","Humans","Models, Biological","Nervous System Diseases","Signal Transduction"],"mesh_terms":["CX3C Chemokine Receptor 1","Animals","Humans","Models, Biological","Nervous System Diseases","Signal Transduction","Chemokine CX3CL1"],"keywords":["CX3CR1","CX3CL1","Microglia","Neuroscience","Neuropathology","Neuroinflammation","Central nervous system","Chemokine","Biology","Inflammation","Medicine","Immunology","Disease","Chemokine receptor","Pathology","Epilepsy","Neurodegenerative diseases","Cerebral ischemia","Alzheimer’s disease","fractalkine","Parkinson’s Disease"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"doi"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-29T19:02:53.439680Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}