{"doi":"10.3390/cells9040966","title":"A Dense Fibrillar Collagen Scaffold Differentially Modulates Secretory Function of iPSC-Derived Vascular Smooth Muscle Cells to Promote Wound Healing","abstract":"The application of human-induced pluripotent stem cells (hiPSCs) to generate vascular smooth muscle cells (hiPSC-VSMCs) in abundance is a promising strategy for vascular regeneration. While hiPSC-VSMCs have already been utilized for tissue-engineered vascular grafts and disease modeling, there is a lack of investigations exploring their therapeutic secretory factors. The objective of this manuscript was to understand how the biophysical property of a collagen-based scaffold dictates changes in the secretory function of hiPSC-VSMCs while developing hiPSC-VSMC-based therapy for durable regenerative wound healing. We investigated the effect of collagen fibrillar density (CFD) on hiPSC-VSMC's paracrine secretion and cytokines via the construction of varying density of collagen scaffolds. Our study demonstrated that CFD is a key scaffold property that modulates the secretory function of hiPSC-VSMCs. This study lays the foundation for developing collagen-based scaffold materials for the delivery of hiPSC-VSMCs to promote regenerative healing through guiding paracrine signaling pathways.","journal":"Cells","year":2020,"id":96441,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":34,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.956,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":478403,"name":"Ocean Setia","orcid":null,"position":1,"is_corresponding":false},{"id":310301,"name":"Jolanta Gorecka","orcid":"0000-0001-9131-3704","position":2,"is_corresponding":false},{"id":477808,"name":"Hassan Peyvandi","orcid":"0000-0003-2891-0877","position":3,"is_corresponding":false},{"id":478404,"name":"Kaiti Duan","orcid":null,"position":4,"is_corresponding":false},{"id":477809,"name":"Lara Lopes","orcid":"0000-0001-6472-4903","position":5,"is_corresponding":false},{"id":477810,"name":"James Nie","orcid":"0000-0002-4692-2743","position":6,"is_corresponding":false},{"id":447375,"name":"François Berthiaume","orcid":"0000-0002-6914-4876","position":7,"is_corresponding":false},{"id":258727,"name":"Alan Dardik","orcid":"0000-0001-5022-7367","position":8,"is_corresponding":false},{"id":310306,"name":"Henry C. Hsia","orcid":"0000-0001-8674-9140","position":9,"is_corresponding":false},{"id":310304,"name":"Biraja C. Dash","orcid":"0000-0002-1795-3284","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-18T22:34:34.781847Z","pmid":"32295218","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}