{"doi":"10.3390/cells9030579","title":"From Synthesis to Utilization: The Ins and Outs of Mitochondrial Heme","abstract":"Heme is a ubiquitous and essential iron containing metallo-organic cofactor required for virtually all aerobic life. Heme synthesis is initiated and completed in mitochondria, followed by certain covalent modifications and/or its delivery to apo-hemoproteins residing throughout the cell. While the biochemical aspects of heme biosynthetic reactions are well understood, the trafficking of newly synthesized heme-a highly reactive and inherently toxic compound-and its subsequent delivery to target proteins remain far from clear. In this review, we summarize current knowledge about heme biosynthesis and trafficking within and outside of the mitochondria.","journal":"Cells","year":2020,"id":51797,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":147,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9527,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":259687,"name":"Courtney M. Moore","orcid":"0000-0001-8303-7164","position":1,"is_corresponding":false},{"id":261362,"name":"Jason R. Marcero","orcid":null,"position":2,"is_corresponding":false},{"id":259688,"name":"Amy E. Medlock","orcid":"0000-0001-9402-3593","position":3,"is_corresponding":false},{"id":259689,"name":"Amit R. Reddi","orcid":"0000-0003-3952-404X","position":4,"is_corresponding":false},{"id":259690,"name":"Oleh Khalimonchuk","orcid":"0000-0002-3972-8678","position":5,"is_corresponding":false},{"id":259686,"name":"Samantha Swenson","orcid":"0000-0002-5650-3841","position":0,"is_corresponding":true}],"reference_count":263,"raw_metadata":null,"created_at":"2026-07-18T20:41:30.009880Z","pmid":"32121449","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}